COVID-19, caused by SARS-CoV-2, is characterised by a broad spectrum of symptom severity that requires varying amounts of care according to the different stages of the disease. Intervening at the onset of mild to moderate COVID-19 symptoms in the outpatient setting would provide the opportunity to prevent progression to a more severe illness and long-term complications. As early disease symptoms variably reflect an underlying excessive inflammatory response to the viral infection, the use of anti-inflammatory drugs, especially non-steroidal anti-inflammatory drugs (NSAIDs), in the initial outpatient stage of COVID-19 seems to be a valuable therapeutic strategy. A few observational studies have tested NSAIDs (especially relatively selective COX-2 inhibitors), often as part of multipharmacological protocols, for early outpatient treatment of COVID-19. The findings from these studies are promising and point to a crucial role of NSAIDs for the at-home management of people with initial COVID-19 symptoms.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411261

Home as the new frontier for the treatment of COVID-19: the case for anti-inflammatory agents

The invention concerns a method and system for the prediction of aircrafts vertical trajectory, in particular for Air Traffic Management, comprising the following flight calculation modules: Take-off; Climb; Cruise; Descent; and Landing, corresponding to the relevant flight phases, wherein: the calculation of the predicted aircraft trajectory is effected by using a set of TEM equations comprising, as output variables, the vertical rate of climb or descent, the true air speed, the energy share factor, the thrust and the drag, the mass of the aircraft modeled as point-mass, and comprising, as inpu variables, the Mach number depending on true air speed and temperature and altitude, the gravity acceleration, and the fuel flow, and the flight path angle; the calculation of the predicted aircraft trajectory for Cruise phase, wherein only the mass is varying, is performed by using the following analytical solution to said set of TEM equations.

Fast vertical trajectory prediction method for air traffic management, and relevant atm system

The different advantageous embodiments provide a system for generating trajectory predictions for a flight comprising a flight object manager and a trajectory predictor. The flight object manager is configured to generate flight information using a number of flight plans, a number of flight schedules, and flight status information. The trajectory predictor is configured to receive flight information from the flight object manager and use the flight information to generate the trajectory predictions.

Tailored arrivals allocation system trajectory predictor

A method of selecting weather data for use in at least one of a flight management system (FMS) of an aircraft and a ground station includes selecting a reduced set of weather data points to send to the FMS and taking into account a trajectory of the aircraft when determining what data points to include in the reduced set.

Meteorological data selection along an aircraft trajectory

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused severe illness and mortality for millions worldwide. Despite the development, approval and rollout of vaccination programmes globally to prevent infection by SARS-CoV-2 and the development of coronavirus disease 2019 (COVID-19), treatments are still urgently needed to improve outcomes. Early in the pandemic it was observed that patients with pre-existing asthma or COPD were underrepresented among those with COVID-19. Evidence from clinical studies indicates that the inhaled corticosteroids (ICS) routinely taken for asthma and COPD could have had a protective role in preventing severe COVID-19 and, therefore, may be a promising treatment for COVID-19. This review summarises the evidence supporting the beneficial effects of ICS on outcomes in patients with COVID-19 and explores the potential protective mechanisms. Treatments are urgently needed to improve outcomes for patients with coronavirus disease 2019 (COVID-19) infection. This review summarises the evidence for the potential protective role of inhaled corticosteroids in preventing severe COVID-19 https://bit.ly/3yCAvfn

/pdf/inhaled-corticosteroids-for-the-treatment-of-covid-19-2kls4ncf.pdf

Inhaled corticosteroids for the treatment of COVID-19

The invention consists in merging together the predicted and measured meteorological data to supply them to the flight prediction calculation system so as to smooth the discontinuities brought about in the prior art by the simple update which is carried out This merging is advantageously done by linear weighting of the data, the weighting coefficient depending upon the positioning in vertical and horizontal distances between the predicted point and the aeroplane in relation to chosen thresholds

System and Method for Merging Meteorological Data Predicted and Measured on an Aircraft

The invention relates to a system and a method for calculating flight predictions of an aircraft in which an intermediate prediction horizon is defined between the flight phase and the leg. This horizon, that is called vertical section, is defined such that the limit conditions that are applicable to it, for example the target speed, target altitude, characteristic altitude and maximum end-of-section distance, are valid for the entire vertical section. Thus, it is not necessary, in calculations to check the compatibility of the flight parameters with the applicable constraints, to arbitrarily select the constraint that must be given priority. Furthermore, this intermediate level architecture allows for a greater modularity of the prediction management software and therefore a greater factorization of the developments and greater ease of maintenance.

System and Method for Calculating Flight Predictions by Vertical Sections

L'invention concerne un systeme et un procede de calcul des predictions de vol d'un aeronef dans lesquels on definit un horizon de prediction intermediaire entre la phase de vol et le segment. Cet horizon, que l'on appelle section verticale, est defini de telle sorte que les conditions aux limites qui lui sont applicables, par exemple la vitesse cible, l'altitude cible, l'altitude caracteristique et la distance maximale de fin de section, sont valides pour toute la section verticale. Ainsi, il n'est pas necessaire, lors des calculs de verification de la compatibilite des parametres de vol avec les contraintes applicables, de choisir arbitrairement la contrainte qui doit etre privilegiee. En outre, cette architecture a niveau intermediaire permet une modularite plus grande du logiciel de gestion des predictions et donc une factorisation plus importante des developpements et une plus grande facilite de maintenance.

Systeme et procede de calcul des predictions de vol par sections verticales

L'invention consiste a fusionner ensemble les donnees meteorologiques predites et mesurees pour les fournir au systeme de calcul des predictions de vol de maniere a lisser les discontinuites qu'entraine dans l'art anterieur le recalage simple effectue. Cette fusion s'opere avantageusement par ponderation lineaire des donnees, le coefficient de ponderation dependant du positionnement en distances verticale et horizontale point predit/avion en relation avec des seuils choisis.

Systeme et procede de fusion des donnees meteorologiques predites et mesurees sur aeronef

The invention is to merge all the predicted weather data and measured to provide the system for calculating flight predictions so as to smooth the discontinuities in the prior art entails the simple registration made This fusion is advantageously carried out by linear weighting of the data, the weighting coefficient depending on the positioning in the vertical and horizontal distances predicted point / plane in relation selected thresholds

System and melting process meteorological measured and predicted data on aircraft

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