Alexandra W. C. Einerhand
Boston Children's Hospital
85 Papers
1.2K Citations
Alexandra W. C. Einerhand is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Mucin & Mucin 2. The author has an hindex of 39, co-authored 82 publications. Previous affiliations of Alexandra W. C. Einerhand include University of Amsterdam & Erasmus University Rotterdam.
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Papers
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
Maria van der Sluis,Barbara A. E. de Koning,Adrianus C. J. M. de Bruijn,Anna Velcich,Jules P.P. Meijerink,Johannes B. van Goudoever,Hans A. Büller,Jan Dekker,Isabelle Van Seuningen,Ingrid B. Renes,Alexandra W. C. Einerhand +10 more
TL;DR: This study shows that Muc2 deficiency leads to inflammation of the colon and contributes to the onset and perpetuation of experimental colitis.
1.6K
The MUC family: an obituary.
TL;DR: It is suggested that the mucin genes be renamed according to their sequence homology, suggesting the existence of one large gene family.
399
Mucin gene structure and expression: protection vs. adhesion
TL;DR: Two classes of mucins are described: epithelium-associated and endothelium/leukocyte-associated mucins, which have thus far been described separately in the literature.
354
Activation of PPAR gamma and alpha by punicic acid ameliorates glucose tolerance and suppresses obesity-related inflammation.
Raquel Hontecillas,Marianne O'Shea,Alexandra W. C. Einerhand,Margaret DiGuardo,Josep Bassaganya-Riera +4 more
TL;DR: It is demonstrated that PUA binds and robustly activates PPAR γ, increases PPAR α- and γ-responsive gene expression and the loss of PPar γ in immune cells impairs its ability to ameliorate diabetes and inflammation.
166
Intestinal Brush Border Glycohydrolases: Structure, Function, and Development
TL;DR: This review will critically discuss all that is known in the literature about intestinal brush border glycohydrolases with respect to structure, biosynthesis, substrate specificity, hydrolytic mechanism, gene regulation and developmental expression.
164