Alexandra Silva
Instituto de Biologia Molecular e Celular
32 Papers
77 Citations
Alexandra Silva is an academic researcher from Instituto de Biologia Molecular e Celular. The author has contributed to research in topics: Biology & Computer science. The author has an hindex of 12, co-authored 28 publications. Previous affiliations of Alexandra Silva include RMIT University & University of Porto.
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Papers
Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity
Ana Mesquita,Martin Weinberger,Alexandra Silva,Belém Sampaio-Marques,Bruno Almeida,Cecília Leão,Vítor Costa,Fernando Rodrigues,William C. Burhans,Paula Ludovico +9 more
TL;DR: A role for hormesis effects of hydrogen peroxide in promoting longevity is established in Saccharomyces cerevisiae by inducing elevated levels of the reactive oxygen species hydrogenperoxide, which activate superoxide dismutases that inhibit the accumulation of superoxide anions.
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SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy
Belém Sampaio-Marques,Carolina Felgueiras,Alexandra Silva,Márcio Rodrigues,Sandra Tenreiro,Vanessa Franssens,Andreas S. Reichert,Tiago F. Outeiro,Joris Winderickx,Paula Ludovico +9 more
TL;DR: Increased mitophagy activity, mediated by the regulation of ATG32 by Sir2, is an important phenomenon linked to SNCA-induced toxicity during aging, and shows that Sir2 functions as a regulator of autophagy, like its mammalian homolog, SIRT1, but also ofMitophagy.
125
Accumulation of organic carbon in five Brazilian lakes during the Holocene
Bruno Turcq,Ana Luiza Spadano Albuquerque,Renato Campello Cordeiro,A. Sifeddine,A. Sifeddine,F. L. Simões Filho,A.G Souza,Jorge Abrao,F.B.L Oliveira,Alexandra Silva,J Capitâneo +10 more
TL;DR: In this article, a comparative study was made of organic carbon accumulation in five lacustrine environments in Brazil (large open water lake, ponds with floating meadows and marshes) using the most representative cores to calculate the accumulation of total organic carbon (TOC) in the sediment over the past 12,000 cal years BP.
102
Drug-induced apoptosis in yeast.
Bruno Almeida,Alexandra Silva,Ana Mesquita,Belém Sampaio-Marques,Fernando Rodrigues,Paula Ludovico +5 more
TL;DR: The evidence presented suggests that yeasts may be a powerful model for the screening/development of PCD-directed drugs, overcoming the problem of cellular specificity in the design of antitumour drugs, but also enabling theDesign of efficient antifungal drugs, targeted to fungal-specific apoptotic regulators that do not have major consequences for human cells.
77
Systemic macrophage and neutrophil destruction by secondary necrosis induced by a bacterial exotoxin in a Gram-negative septicaemia.
Ana do Vale,Carolina Costa-Ramos,Alexandra Silva,Daniela S.P. Silva,Fátima Gärtner,Nuno M.S. dos Santos,Manuel T. Silva +6 more
TL;DR: The induction by a bacterial exotoxin of in vivo systemic lysis of both professional phagocytes by secondary necrosis may represent an overlooked etiopathogenic mechanism operating in other infections of vertebrates.
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