Alexandra Jilkine
University of Notre Dame
24 Papers
157 Citations
Alexandra Jilkine is an academic researcher from University of Notre Dame. The author has contributed to research in topics: Stem cell & Progenitor cell. The author has an hindex of 12, co-authored 20 publications. Previous affiliations of Alexandra Jilkine include University of British Columbia & University of Texas Southwestern Medical Center.
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Papers
Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration
Andrew R. Houk,Alexandra Jilkine,Cecile O. Mejean,Rostislav Boltyanskiy,Eric R. Dufresne,Sigurd Angenent,Steven J. Altschuler,Lani F. Wu,Orion D. Weiner +8 more
TL;DR: It is suggested that tension, rather than diffusible molecules generated or sequestered at the leading edge, is the dominant source of long-range inhibition that constrains the spread of the existing front and prevents the formation of secondary fronts.
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Wave-pinning and cell polarity from a bistable reaction-diffusion system.
TL;DR: The mathematical basis of the phenomenon is explained, it is related to spatial segregation of Rho GTPases, and it is shown how it can account for spatial amplification and maintenance of polarity, as well as sensitivity to new stimuli typical in polarization of eukaryotic cells.
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Asymptotic and bifurcation analysis of wave-pinning in a reaction-diffusion model for cell polarization
TL;DR: In this article, a bistable reaction-diffusion (RD) model for two interconverting chemical species that exhibits a phenomenon of wave-pinning is described and analyzed.
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Effect of dedifferentiation on time to mutation acquisition in stem cell-driven cancers.
TL;DR: Dedifferentiation may play an important role in carcinogenesis, depending on how stem cell homeostasis is maintained, and the common modeling assumption of constant stem cell population size may not be adequate, and further progress in understanding carcinogenesis demands a more detailed mechanistic understanding of stem cellHomeostasis.
On-membrane digestion of β-casein for determination of phosphorylation sites by matrix-assisted laser desorption/ionization quadrupole/time-of-flight mass spectrometry
C. H. Lee,Mark E. McComb,M. Bromirski,Alexandra Jilkine,Werner Ens,Kenneth G. Standing,H. Perreault +6 more
TL;DR: In this article, a matrix-assisted laser desorption/ionization quadrupole/time-of-flight (MALDI-QqTOF) mass spectrometer was used for the analysis of phosphorylated peptides.
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