Alexandra C. Newton
University of California, San Diego
238 Papers
3.6K Citations
Alexandra C. Newton is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Protein kinase C & Phosphorylation. The author has an hindex of 73, co-authored 218 publications. Previous affiliations of Alexandra C. Newton include Stanford University & University of California.
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Papers
p21-activated Kinase (PAK1) Is Phosphorylated and Activated by 3-phosphoinositide-dependent kinase-1 (PDK1)
Charles C. King,Elisabeth M. Gardiner,Frank Zenke,Benjamin P. Bohl,Alexandra C. Newton,Brian A. Hemmings,Gary M. Bokoch +6 more
TL;DR: Evidence is provided for a novel mechanism for PAK1 regulation and activation that is independent of phosphatidylinositol 3-kinase activity and based on the observation that these two proteins interact in vivo and that PDK1-phosphorylatedPAK1 has an increased activity toward substrate.
254
Protein kinase C: perfectly balanced.
TL;DR: The tightly controlled mechanisms that ensure PKC activity is perfectly balanced are described and what happens when these controls are deregulated are described.
Mechanism of Interaction of Protein Kinase C with Phorbol Esters REVERSIBILITY AND NATURE OF MEMBRANE ASSOCIATION
TL;DR: The results are consistent with protein kinase C binding reversibly to PMA- or DG-containing membranes primarily via interactions at the membrane interface.
249
Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol.
TL;DR: The pseudosubstrate domain of protein kinase C is cleaved after the first residue, arginine 19, by the endoproteinase Arg-C only when the kinase is bound to the activating lipid phosphatidylserine.
201