Alexandra Beck
Wellcome Trust Sanger Institute
7 Papers
79 Citations
Alexandra Beck is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Biology & Drug. The author has an hindex of 2, co-authored 2 publications.
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Papers
Effective drug combinations in breast, colon and pancreatic cancer cells
Patricia Jaaks,Elizabeth A. Coker,Daniel J. Vis,Olivia Edwards,Emma F. Carpenter,Simonetta Maria Leto,Lisa Dwane,Francesco Sassi,Howard Lightfoot,Syd Barthorpe,Dieudonne van der Meer,Wanjuan Yang,Alexandra Beck,Tatiana Mironenko,Caitlin Hall,James Hall,Iman Mali,Laura Richardson,Charlotte Tolley,James Morris,Frances Thomas,Ermira Lleshi,Nanne Aben,Cyril H. Benes,Andrea Bertotti,Livio Trusolino,Lodewyk F. A. Wessels,Mathew J. Garnett +27 more
TL;DR: In this paper , the potency and efficacy of 2,025 clinically relevant two-drug combinations were evaluated, generating a dataset encompassing 125 molecularly characterized breast, colorectal and pancreatic cancer cell lines.
Pan-cancer proteomic map of 949 human cell lines
Emanuel Gonçalves,Rebecca C. Poulos,ZhaoXiang Cai,Syd Barthorpe,Srikanth S. Manda,Natasha Lucas,Alexandra Beck,Daniel Bucio-Noble,Michael Dausmann,Caitlin Hall,Michael Hecker,Jennifer M. S. Koh,Sadia Mahboob,Iman Mali,James Morris,Laura Richardson,Akila J. Seneviratne,Erin K. Sykes,Frances Thomas,Sara Valentini,Steven G. Williams,Yangxiu Wu,Dylan Xavier,Karen L. MacKenzie,Peter G. Hains,Brett Tully,Philip Robinson,Qing Zhong,Mathew J. Garnett,Roger R. Reddel +29 more
TL;DR: Ghandi et al. as discussed by the authors used a deep learning-based pipeline to find biomarkers of drug response and gene essentiality, and showed that random downsampling to only 1,500 proteins has limited impact on predictive power, consistent with protein networks being highly connected and coregulated.
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The origins and vulnerabilities of two transmissible cancers in Tasmanian devils
Maximilian R Stammnitz,Tim H. H. Coorens,Kevin Gori,Dane Hayes,Beiyuan Fu,Jinhong Wang,Daniel E. Martin-Herranz,Ludmil B. Alexandrov,Adrian Baez-Ortega,Syd Barthorpe,Alexandra Beck,Francesca Giordano,Graeme W. Knowles,Young Mi Kwon,George T. Hall,Stacey Price,Ruth J. Pye,Jose M. C. Tubio,Hannah V. Siddle,Sukhwinder Singh Sohal,Gregory M. Woods,Ultan McDermott,Fengtang Yang,Mathew J. Garnett,Zemin Ning,Elizabeth P. Murchison +25 more
TL;DR: It is implied that Tasmanian devils may have inherent susceptibility to transmissible cancers and present a suite of therapeutic compounds for use in conservation.
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Effective drug combinations in breast, colon and pancreatic cancer cells
Patricia Jaaks,Elizabeth A. Coker,Daniel J. Vis,Olivia Edwards,Emma F. Carpenter,Simonetta Maria Leto,Lisa Dwane,Francesco Sassi,Howard Lightfoot,Syd Barthorpe,Dieudonne van der Meer,Wanjuan Yang,Alexandra Beck,Tatiana Mironenko,Caitlin Hall,James Hall,Iman Mali,Laura Richardson,Charlotte Tolley,J. Morris,Frances Thomas,Ermira Lleshi,Nanne Aben,Cyril H. Benes,Andrea Bertotti,Livio Trusolino,Lodewyk F. A. Wessels,Mathew J. Garnett +27 more
TL;DR: In this paper , the potency and efficacy of 2,025 clinically relevant two-drug combinations were evaluated, generating a dataset encompassing 125 molecularly characterized breast, colorectal and pancreatic cancer cell lines.
Large-scale Pan-cancer Cell Line Screening Identifies Actionable and Effective Drug Combinations.
A. Bashi,Elizabeth A. Coker,Krishna C. Bulusu,Patricia Jaaks,Claire Crafter,Howard Lightfoot,Marta Milo,Katrina McCarten,David F Jenkins,Dieudonne van der Meer,James T Lynch,Syd Barthorpe,Courtney L Andersen,Simon T Barry,Alexandra Beck,Justin Cidado,Jacob A Gordon,Caitlin Hall,James Hall,Iman Mali,Tatiana Mironenko,Kevin Mongeon,J. Morris,Laura Richardson,Paul Smith,Omid Tavana,Charlotte Tolley,Frances Thomas,Brandon S Willis,Wanjuan Yang,Mark J O'Connor,Ultan McDermott,Susan E. Critchlow,Lisa Drew,Stephen Fawell,Jerome T. Mettetal,Mathew J Garnett +36 more
TL;DR: Large-scale pan-cancer cell line screening identifies actionable and effective drug combinations.
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