Alexander Y. Rudensky
Memorial Sloan Kettering Cancer Center
286 Papers
2.3K Citations
Alexander Y. Rudensky is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: FOXP3 & Biology. The author has an hindex of 116, co-authored 268 publications. Previous affiliations of Alexander Y. Rudensky include University of Washington & Yale University.
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Papers
Requirement for Diverse, Low-Abundance Peptides in Positive Selection of T Cells
TL;DR: A diverse population of self peptides was shown to be essential for the in vivo development of CD4 T cells, indicating that positive selection occurred on the diverse peptides present at low levels.
IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
Georg Gasteiger,Saskia Hemmers,Matthew A. Firth,Audrey Le Floc’h,Morgan Huse,Joseph C. Sun,Alexander Y. Rudensky +6 more
TL;DR: IL-2–dependent adaptive-innate lymphocyte cross talk tunes NK cell reactivity and is limited by T reg cells.
The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis.
FangWei Leng,Wenxiang Zhang,Ricardo Ramirez,Juliette Leon,Yi Zhong,Lifei Hou,Koichi Yuki,Joris van der Veeken,Alexander Y. Rudensky,Christophe Benoist,Sun Hur +10 more
TL;DR: In this paper , Nitta et al. showed that FoxP3 formed a head-to-head dimer using a unique linker (Runx1-binding region [RBR]) preceding the forkhead domain.
CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow
Shlomo Elias,Rahul Sharma,Michael Schizas,Izabella Valdez,Sham Rampersaud,Sun-Mi Park,Paula Gonzalez-Figueroa,Quan Zhen Li,Beatrice Hoyos,Alexander Y. Rudensky +9 more
TL;DR: In this article , the authors show that continuous expression of the chemokine receptor CXCR4 in Treg cells is required for their ability to accumulate in the bone marrow (BM).
Transcriptional control of regulatory T-cell differentiation.
TL;DR: Mechanisms of gene regulation that underlie Treg-cell differentiation and function are discussed with an emphasis on studies from the laboratory.