Alexander Y. Rudensky
Memorial Sloan Kettering Cancer Center
286 Papers
2.3K Citations
Alexander Y. Rudensky is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: FOXP3 & Biology. The author has an hindex of 116, co-authored 268 publications. Previous affiliations of Alexander Y. Rudensky include University of Washington & Yale University.
Chat about Author
Papers
Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1.
TL;DR: The results suggest that the TCR signal is sufficient for transcriptional activation of Foxp3 in the absence of maintenance DNA methylation and that TGF-β facilitatesFoxp3 induction in part by opposing cell cycle-dependent Dnmt1 recruitment, leading to locus inactivation.
165
Glycolysis Fuels Phosphoinositide 3-Kinase Signaling to Bolster T Cell Immunity
Ke Xu,Na Yin,Na Yin,Min Peng,Min Peng,Efstathios G. Stamatiades,Amy Shyu,Peng Li,Xian Zhang,Mytrang H. Do,Mytrang H. Do,Zhaoquan Wang,Zhaoquan Wang,Kristelle J. Capistrano,Chun Chou,Andrew G. Levine,Andrew G. Levine,Alexander Y. Rudensky,Alexander Y. Rudensky,Ming O. Li,Ming O. Li +20 more
TL;DR: It is shown that the glycolytic enzyme lactate dehydrogenase A is induced in CD8+ T effector cells via phosphoinositide 3-kinase (PI3K)-dependent mechanisms, resulting in attenuated PI3K signaling.
Survival and Homeostatic Proliferation of Naive Peripheral CD4+ T Cells in the Absence of Self Peptide:MHC Complexes
TL;DR: The results show that the factors regulating survival and homeostatic expansion of naive T cells in the periphery are not identical, and provide evidence for a novel form of T cell proliferation that can occur independently of TCR signaling and suggest that this reflects another mechanism regulatingHomeostatic T cell expansion.
Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota
Blossom Akagbosu,Zakieh Tayyebi,G. Shibu,Yoselin A. Paucar Iza,Deeksha Deep,Yollanda Franco Parisotto,Logan Fisher,H. Amalia Pasolli,Valentin Thevin,Rasa Elmentaite,Maximilian M. L. Knott,Saskia Hemmers,Lorenz Jahn,Christin Friedrich,Jacob Verter,Zhong-Min Wang,Marcel R.M. van den Brink,Georg Gasteiger,Thomas G P Grünewald,Julien C. Marie,Christina S. Leslie,Alexander Y. Rudensky,Chrysothemis C. Brown +22 more
TL;DR: In this article , the identification of a class of RORγt + antigen-presenting cells called Thetis cells, with transcriptional features of both mTECs and dendritic cells, comprising four major subgroups (TC I-TC IV).
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells
Takashi Sekiya,Ikkou Kashiwagi,Naoko Inoue,Rimpei Morita,Shohei Hori,Herman Waldmann,Alexander Y. Rudensky,Hiroshi Ichinose,Daniel Metzger,Pierre Chambon,Akihiko Yoshimura +10 more
TL;DR: Nr4a2 has the ability to maintain T-cell homoeostasis by regulating induction, maintenance and suppressor functions of Tregs, and by repression of aberrant Th1 induction.
142