Alexander Weiss
Lunenfeld-Tanenbaum Research Institute
4 Papers
Alexander Weiss is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: Hippo signaling pathway & Hippo signaling. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Alexander Weiss include Mount Sinai Hospital, Toronto.
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Papers
The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway
Xaralabos Varelas,Payman Samavarchi-Tehrani,Payman Samavarchi-Tehrani,Masahiro Narimatsu,Alexander Weiss,Katie Cockburn,Brett Larsen,Janet Rossant,Jeffrey L. Wrana,Jeffrey L. Wrana +9 more
TL;DR: It is demonstrated that TAZ/YAP dictate the localization of active SMAD complexes in response to cell density-mediated formation of polarity complexes, and that disruption of the Crumbs complex enhances TGF-β signaling and predisposes cells to T GF-β-mediated epithelial-to-mesenchymal transitions.
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Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions
Amber L. Couzens,James D.R. Knight,Michelle J. Kean,Michelle J. Kean,Guo Ci Teo,Alexander Weiss,Wade H. Dunham,Zhen-Yuan Lin,Richard D. Bagshaw,Frank Sicheri,Frank Sicheri,Tony Pawson,Tony Pawson,Jeffrey L. Wrana,Jeffrey L. Wrana,Hyungwon Choi,Anne-Claude Gingras,Anne-Claude Gingras +17 more
TL;DR: Results indicated that changes in phosphorylation orchestrate interactions between kinases and phosphatases in Hippo signaling, providing a putative mechanism for pathway regulation.
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Switch Enhancers Interpret TGF-β and Hippo Signaling to Control Cell Fate in Human Embryonic Stem Cells
Tobias A. Beyer,Alexander Weiss,Yuliya Khomchuk,Kui Huang,Abiodun A. Ogunjimi,Xaralabos Varelas,Jeffrey L. Wrana,Jeffrey L. Wrana +7 more
TL;DR: These studies define switch-enhancer elements and provide a framework to understand how cellular context dictates interpretation of the same morphogen signal in development.
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The TGFβ superfamily in stem cell biology and early mammalian embryonic development.
Tobias A. Beyer,Masahiro Narimatsu,Alexander Weiss,Laurent David,Jeffrey L. Wrana,Jeffrey L. Wrana +5 more
TL;DR: TGFβ family signals are essential for early mammalian development and the importance of this pathway is reflected in pluripotent stem cells derived from the mammalian embryo.
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