Alexander Stephan
University of Copenhagen
2 Papers
20 Citations
Alexander Stephan is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Calmodulin & Gene. The author has an hindex of 2, co-authored 2 publications.
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Papers
Regulation of the Ligand-dependent Activation of the Epidermal Growth Factor Receptor by Calmodulin
Hongbing Li,Svetlana Panina,Amandeep Kaur,María José Ruano,Pablo Sánchez-González,Jonas M. la Cour,Alexander Stephan,Uffe H. Olesen,Martin W. Berchtold,Antonio Villalobo +9 more
TL;DR: The hypothesis that Ca2+/CaM regulates the EGFR activity by directly interacting with the CaM-BD of the receptor located at its cytosolic juxtamembrane region is supported.
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Significance of calcium binding, tyrosine phosphorylation, and lysine trimethylation for the essential function of calmodulin in vertebrate cells analyzed in a novel gene replacement system.
Svetlana Panina,Alexander Stephan,Jonas M. la Cour,Kivin Jacobsen,Line K. Kallerup,Rasita Bumbuleviciute,Kristoffer V. K. Knudsen,Pablo Sánchez-González,Antonio Villalobo,Uffe H. Olesen,Martin W. Berchtold +10 more
TL;DR: It is shown that CaM is essential for survival of vertebrate cells as they die in the absence of CaM expression, and this system offers a unique opportunity to analyze CaM structure-function relationships in vivo without the use of pharmacological inhibitors.
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