Alexander P. Reiner
University of Washington
503 Papers
3.1K Citations
Alexander P. Reiner is an academic researcher from University of Washington. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 83, co-authored 412 publications. Previous affiliations of Alexander P. Reiner include Georgetown University & University of Groningen.
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Papers
DNA methylation-based measures of biological age: meta-analysis predicting time to death
Brian H. Chen,Riccardo E. Marioni,Riccardo E. Marioni,Elena Colicino,Marjolein J. Peters,Cavin K. Ward-Caviness,Pei-Chien Tsai,Nicholas S. Roetker,Allan C. Just,Ellen W. Demerath,Weihua Guan,Jan Bressler,Myriam Fornage,Myriam Fornage,Stephanie A. Studenski,Amy R. Vandiver,Ann Zenobia Moore,Toshiko Tanaka,Douglas P. Kiel,Liming Liang,Pantel S. Vokonas,Joel Schwartz,Kathryn L. Lunetta,Kathryn L. Lunetta,Joanne M. Murabito,Joanne M. Murabito,Stefania Bandinelli,Dena G. Hernandez,David Melzer,Mike A. Nalls,Luke C. Pilling,Timothy Ryan Price,Andrew B. Singleton,Christian Gieger,Rolf Holle,Anja Kretschmer,Florian Kronenberg,Sonja Kunze,Jakob Linseisen,Christine Meisinger,Wolfgang Rathmann,Melanie Waldenberger,Peter M. Visscher,Peter M. Visscher,Sonia Shah,Naomi R. Wray,Allan F. McRae,Oscar H. Franco,Albert Hofman,Albert Hofman,André G. Uitterlinden,Devin Absher,Themistocles L. Assimes,Morgan E. Levine,Ake T. Lu,Philip S. Tsao,Philip S. Tsao,Lifang Hou,JoAnn E. Manson,Cara L. Carty,Andrea Z. LaCroix,Alexander P. Reiner,Alexander P. Reiner,Tim D. Spector,Andrew P. Feinberg,Daniel Levy,Andrea A. Baccarelli,Andrea A. Baccarelli,Joyce B. J. van Meurs,Jordana T. Bell,Annette Peters,Ian J. Deary,James S. Pankow,Luigi Ferrucci,Steve Horvath +74 more
- 28 Sep 2016
TL;DR: Evidence that epigenetic age predicts all-cause mortality above and beyond chronological age and traditional risk factors is strengthened and estimates that incorporate information on blood cell counts lead to highly significant associations with all- Cause mortality are demonstrated.
Loss-of-function mutations in APOC3, triglycerides, and coronary disease
Jacy R Crosby,Gina M. Peloso,Gina M. Peloso,Paul L. Auer,David R. Crosslin,Nathan O. Stitziel,Leslie A. Lange,Yingchang Lu,Zheng-Zheng Tang,He Zhang,George Hindy,Nicholas G. D. Masca,Kathleen Stirrups,Stavroula Kanoni,Ron Do,Ron Do,Goo Jun,Youna Hu,Hyun Min Kang,Chenyi Xue,Anuj Goel,Martin Farrall,Stefano Duga,Pier Angelica Merlini,Rosanna Asselta,Domenico Girelli,Oliviero Olivieri,Nicola Martinelli,Wu Yin,Dermot F. Reilly,Elizabeth K. Speliotes,Caroline S. Fox,Kristian Hveem,Oddgeir L. Holmen,Majid Nikpay,Deborah N. Farlow,Themistocles L. Assimes,Nora Franceschini,Jennifer G. Robinson,Kari E. North,Lisa W. Martin,Mark A. DePristo,Namrata Gupta,Stefan A. Escher,Jan-Håkan Jansson,Natalie R. van Zuydam,Colin N. A. Palmer,Nicholas J. Wareham,Werner Koch,Thomas Meitinger,Annette Peters,Wolfgang Lieb,Raimund Erbel,Inke R. König,Jochen Kruppa,Franziska Degenhardt,Omri Gottesman,Erwin P. Bottinger,Christopher J. O'Donnell,Bruce M. Psaty,Bruce M. Psaty,Christie M. Ballantyne,Christie M. Ballantyne,Gonçalo R. Abecasis,Jose M. Ordovas,Jose M. Ordovas,Olle Melander,Hugh Watkins,Marju Orho-Melander,Diego Ardissino,Ruth J. F. Loos,Ruth McPherson,Cristen J. Willer,Jeanette Erdmann,Alistair S. Hall,Nilesh J. Samani,Panos Deloukas,Panos Deloukas,Panos Deloukas,Heribert Schunkert,James G. Wilson,Charles Kooperberg,Stephen S. Rich,Russell P. Tracy,Danyu Lin,David Altshuler,David Altshuler,Stacey Gabriel,Deborah A. Nickerson,Gail P. Jarvik,L. Adrienne Cupples,L. Adrienne Cupples,Alexander P. Reiner,Alexander P. Reiner,Eric Boerwinkle,Sekar Kathiresan,Sekar Kathiresan +96 more
TL;DR: Rare mutations that disrupt AP OC3 function were associated with lower levels of plasma triglycerides and APOC3, and carriers of these mutations were found to have a reduced risk of coronary heart disease.
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Rainer Malik,Ganesh Chauhan,Matthew Traylor,Muralidharan Sargurupremraj,Yukinori Okada,Aniket Mishra,Loes C.A. Rutten-Jacobs,Anne-Katrin Giese,Sander W. van der Laan,Solveig Gretarsdottir,Christopher D. Anderson,Michael Chong,Hieab H.H. Adams,Tetsuro Ago,Peter Almgren,Philippe Amouyel,Hakan Ay,Traci M. Bartz,Oscar R. Benavente,Steve Bevan,Giorgio B. Boncoraglio,Robert D. Brown,Adam S. Butterworth,Caty Carrera,Cara L. Carty,Daniel I. Chasman,Wei-Min Chen,John W. Cole,Adolfo Correa,Ioana Cotlarciuc,Carlos Cruchaga,John Danesh,Paul I.W. de Bakker,Anita L. DeStefano,Marcel den Hoed,Qing Duan,Stefan T. Engelter,Guido J. Falcone,Rebecca F. Gottesman,Raji P. Grewal,Vilmundur Gudnason,Stefan Gustafsson,Jeffrey Haessler,Tamara B. Harris,Ahamad Hassan,Aki S. Havulinna,Susan R. Heckbert,Elizabeth G. Holliday,George Howard,Fang-Chi Hsu,Hyacinth I. Hyacinth,M. Arfan Ikram,Erik Ingelsson,Marguerite R. Irvin,Xueqiu Jian,Jordi Jimenez-Conde,Julie A. Johnson,J. Wouter Jukema,Masahiro Kanai,Keith L. Keene,Brett M. Kissela,Dawn Kleindorfer,Charles Kooperberg,Michiaki Kubo,Leslie A. Lange,Carl D. Langefeld,Claudia Langenberg,Lenore J. Launer,Jin-Moo Lee,Robin Lemmens,Didier Leys,Cathryn M. Lewis,Wei-Yu Lin,Arne Lindgren,Erik Lorentzen,Patrik K. E. Magnusson,Jane Maguire,Ani Manichaikul,Patrick F. McArdle,James F. Meschia,Braxton D. Mitchell,Thomas H. Mosley,Mike A. Nalls,Toshiharu Ninomiya,Martin O'Donnell,Bruce M. Psaty,Sara L. Pulit,Kristiina Rannikmäe,Alexander P. Reiner,Kathryn M. Rexrode,Kenneth Rice,Stephen S. Rich,Paul M. Ridker,Natalia S. Rost,Peter M. Rothwell,Jerome I. Rotter,Tatjana Rundek,Ralph L. Sacco,Saori Sakaue,Michèle M. Sale,Veikko Salomaa,Bishwa Raj Sapkota,Reinhold Schmidt,Carsten Oliver Schmidt,Ulf Schminke,Pankaj Sharma,Agnieszka Slowik,Cathie Sudlow,Christian Tanislav,Turgut Tatlisumak,Kent D. Taylor,Vincent Thijs,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Steffen Tiedt,Stella Trompet,Christophe Tzourio,Cornelia M. van Duijn,Matthew Walters,Nicholas J. Wareham,Sylvia Wassertheil-Smoller,James G. Wilson,Kerri L. Wiggins,Qiong Yang,Salim Yusuf,Joshua C. Bis,Tomi Pastinen,Arno Ruusalepp,Eric E. Schadt,Simon Koplev,Johan Björkegren,Veronica Codoni,Mete Civelek,Nicholas L. Smith,David A. Tregouet,Ingrid E. Christophersen,Carolina Roselli,Steven A. Lubitz,Patrick T. Ellinor,E. Shyong Tai,Jaspal S. Kooner,Norihiro Kato,Jiang He,Pim van der Harst,Paul Elliott,John C. Chambers,Fumihiko Takeuchi,Andrew D. Johnson,Dharambir K. Sanghera,Olle Melander,Christina Jern,Daniel Strbian,Israel Fernandez-Cadenas,W. T. Longstreth,Arndt Rolfs,Jun Hata,Daniel Woo,Jonathan Rosand,Guillaume Paré,Jemma C. Hopewell,Danish Saleheen,Kari Stefansson,Bradford B. Worrall,Steven J. Kittner,Sudha Seshadri,Myriam Fornage,Hugh S. Markus,Joanna M. M. Howson,Yoichiro Kamatani,Stéphanie Debette,Martin Dichgans +170 more
- 01 Jan 2018
TL;DR: A multiancestry genome-wide-association meta-analysis and discovered 22 new stroke risk loci, indicating mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets.
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Genetic analyses of diverse populations improves discovery for complex traits
Genevieve L. Wojcik,Mariaelisa Graff,Katherine K. Nishimura,Ran Tao,Jeffrey Haessler,Christopher R. Gignoux,Christopher R. Gignoux,Heather M. Highland,Yesha Patel,Elena P. Sorokin,Christy L. Avery,Gillian M. Belbin,Stephanie A. Bien,Iona Cheng,Sinead Cullina,Chani J. Hodonsky,Yao Hu,Laura M. Huckins,Janina M. Jeff,Anne E. Justice,Jonathan M. Kocarnik,Unhee Lim,Bridget M Lin,Yingchang Lu,Sarah C. Nelson,Sungshim L. Park,Hannah Poisner,Michael Preuss,Melissa A. Richard,Claudia Schurmann,Claudia Schurmann,Veronica Wendy Setiawan,Alexandra Sockell,Karan Vahi,Marie Verbanck,Abhishek Vishnu,Ryan W. Walker,Kristin L. Young,Niha Zubair,Victor Acuña-Alonso,José Luis Ambite,Kathleen C. Barnes,Eric Boerwinkle,Erwin P. Bottinger,Erwin P. Bottinger,Carlos Bustamante,Christian Caberto,Samuel Canizales-Quinteros,Matthew P. Conomos,Ewa Deelman,Ron Do,Kimberly F. Doheny,Lindsay Fernández-Rhodes,Lindsay Fernández-Rhodes,Myriam Fornage,Benyam Hailu,Gerardo Heiss,Brenna M. Henn,Lucia A. Hindorff,Rebecca D. Jackson,Cecelia A. Laurie,Cathy C. Laurie,Yuqing Li,Yuqing Li,Danyu Lin,Andrés Moreno-Estrada,Girish N. Nadkarni,Paul Norman,Loreall Pooler,Alexander P. Reiner,Jane Romm,Chiara Sabatti,Karla Sandoval,Xin Sheng,Eli A. Stahl,Daniel O. Stram,Timothy A. Thornton,Christina L. Wassel,Lynne R. Wilkens,Cheryl A. Winkler,Sachi Yoneyama,Steven Buyske,Christopher A. Haiman,Charles Kooperberg,Loic Le Marchand,Ruth J. F. Loos,Tara C. Matise,Kari E. North,Ulrike Peters,Eimear E. Kenny,Christopher S. Carlson +90 more
TL;DR: The value of diverse, multi-ethnic participants in large-scale genomic studies is demonstrated and evidence of effect-size heterogeneity across ancestries for published GWAS associations, substantial benefits for fine-mapping using diverse cohorts and insights into clinical implications are shown.
Mendelian randomization of blood lipids for coronary heart disease
Michael V. Holmes,Folkert W. Asselbergs,Tom Palmer,Fotios Drenos,Matthew B. Lanktree,Christopher P. Nelson,Caroline Dale,Sandosh Padmanabhan,Chris Finan,Daniel I. Swerdlow,Vinicius Tragante,Erik P A Van Iperen,Suthesh Sivapalaratnam,Sonia Shah,Clara C. Elbers,Tina Shah,Jorgen Engmann,Claudia Giambartolomei,Jon White,Delilah Zabaneh,Reecha Sofat,Stela McLachlan,Pieter A. Doevendans,Anthony J. Balmforth,Alistair S. Hall,Kari E. North,Berta Almoguera,Ron C. Hoogeveen,Mary Cushman,Myriam Fornage,Sanjay R. Patel,Susan Redline,David S. Siscovick,Michael Y. Tsai,Konrad J. Karczewski,Marten H. Hofker,W. M. Monique Verschuren,Michiel L. Bots,Yvonne T. van der Schouw,Olle Melander,Anna F. Dominiczak,Richard W Morris,Yoav Ben-Shlomo,Jackie F. Price,Meena Kumari,Jens Baumert,Annette Peters,Barbara Thorand,Wolfgang Koenig,Tom R. Gaunt,Steve E. Humphries,Robert Clarke,Hugh Watkins,Martin Farrall,James G. Wilson,Stephen S. Rich,Paul I.W. de Bakker,Leslie A. Lange,George Davey Smith,Alexander P. Reiner,Philippa J. Talmud,Mika Kivimäki,Debbie A Lawlor,Frank Dudbridge,Nilesh J. Samani,Brendan J. Keating,Aroon D. Hingorani,Juan P. Casas +67 more
TL;DR: The genetic findings support a causal effect of triglycerides on CHD risk, but a causal role for HDL-C, though possible, remains less certain.