Alexander Monell
5 Papers
Alexander Monell is an academic researcher. The author has contributed to research in topics: Transcriptome & Biology. The author has an hindex of 2, co-authored 2 publications.
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Papers
Spatially organized cellular communities form the developing human heart.
Elie Farah,Robert K Hu,Colin Kern,Qingquan Zhang,Ting-Yu Lu,Qixuan Ma,Shaina Tran,Bo Zhang,Daniel Carlin,Alexander Monell,Andrew P Blair,Zilu Wang,Jacqueline Eschbach,Bin Li,Eugin Destici,Bing Ren,Sylvia M. Evans,Shaochen Chen,Quan Zhu,Neil C Chi +19 more
TL;DR: Researchers used single-cell RNA-sequencing and fluorescence in situ hybridization to map cardiac cell types in the developing human heart, revealing spatially organized cellular communities that form distinct structures and interact through multicellular signalling pathways.
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Time-resolved single-cell and spatial gene regulatory atlas of plants under pathogen attack
TL;DR: In this paper , the authors present cell atlases with gene regulatory logic involving transcription factors, putative cis-regulatory elements, and target genes associated with disease and immunity.
Functional Diversity of Memory CD8 T Cells is Spatiotemporally Imprinted
Miguel Reina-Campos,Alexander Monell,Amir Ferry,Vida Luna,Kitty P. Cheung,Giovanni Galletti,Nicole E. Scharping,Kennidy K Takehara,Sara Quon,Brigid Boland,Yun Hsuan Elena Lin,William H. Wong,Cynthia Indralingam,Gene W. Yeo,John T. Chang,Maximilian Heeg,Ananda Goldrath +16 more
TL;DR: The spatiotemporal imprint of memory CD8 T cell functional diversity in the small intestine is characterized by distinct transcriptional programs and spatial segregation of subpopulations.
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Bento: A toolkit for subcellular analysis of spatial transcriptomics data
Clarence K. Mah,Noorsher Ahmed,Nicole E. Lopez,Dylan Lam,Alexander Monell,Colin Kern,Yuanyuan Han,Gino Prasad,Anthony J. Cesnik,Emma Lundberg,Quan Zhu,Hannah Carter,Gene W. Yeo +12 more
TL;DR: Bento is a computational framework for subcellular analysis of high-throughput spatial transcriptomics datasets and builds on the existing ecosystem of single-cell and spatial analysis toolkits, to ensure accessibility and community-driven tool development.
Re-activation of neurogenic niches in aging brain
Roy Maimon,Carlos Chillón-Marinas,Sonia Vazquez-Sanchez,Colin Kern,Kresna Jenie,Kseniya Malukhina,Stephen Moore,Jess Cui,Alexander Goginashvili,Siavash Moghadami,Alexander Monell,Melissa McAlonis-Downes,Christine Hong,Paymaan Jafar-Nejad,C. F. Bennett,Quan Zhu,John Ravits,Don W. Cleveland,Bogdan Bintu +18 more
TL;DR: Researchers use single-cell spatial transcriptomics to identify a glial cell population in aged brains that can be reactivated to generate new neurons through transient suppression of the RNA binding protein PTBP1, offering potential therapeutic applications for neurodegenerative diseases.