Alexander M. Lesokhin
Memorial Sloan Kettering Cancer Center
282 Papers
526 Citations
Alexander M. Lesokhin is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Medicine & Multiple myeloma. The author has an hindex of 33, co-authored 138 publications. Previous affiliations of Alexander M. Lesokhin include Cornell University & Bristol-Myers Squibb.
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Papers
Proteomic profiling in plasma cell disorders: a feasibility study.
Sham Mailankody,Sean M. Devlin,Neha Korde,Nikoletta Lendvai,Alexander M. Lesokhin,Heather Landau,Hani Hassoun,Andrea Ballagi,Daniel Ekman,David J. Chung,Minal Patel,Guenther Koehne,Sergio Giralt,Ola Landgren +13 more
TL;DR: This research presents a novel and scalable approach to personalized medicine that addresses the major barriers to effective and efficient use of bone marrow transplantation in patients with central myeloma.
A Phase 1 Study of Nivolumab in Combination with Ipilimumab for Relapsed or Refractory Hematologic Malignancies (CheckMate 039)
Stephen M. Ansell,Martin Gutierrez,Margaret A. Shipp,Douglas E. Gladstone,Alison J. Moskowitz,Ivan Borello,Mihaela Popa-McKiver,Benedetto Farsaci,Lili Zhu,Alexander M. Lesokhin,Philippe Armand +10 more
TL;DR: The aim of this cohort study was to evaluate the safety and efficacy of combined immune checkpoint blockade (nivo+ipi) in patients with the following hematologic malignancies: HL, B-cell non-Hodgkin lymphoma, T-NHL, cutaneous T-cell lymphoma (CTCL] and PTCL]), and multiple myeloma (MM).
Minimal residual disease negativity in multiple myeloma is associated with intestinal microbiota composition.
Matthew J. Pianko,Sean M. Devlin,Eric R. Littmann,Aisara Chansakul,Donna Mastey,Meghan Salcedo,Emily Fontana,Lilan Ling,Elizabet Tavitian,John B. Slingerland,Ann E. Slingerland,Annelie Clurman,Antonio L.C. Gomes,Ying Taur,Eric G. Pamer,Jonathan U. Peled,Jonathan U. Peled,Marcel R.M. van den Brink,Marcel R.M. van den Brink,Ola Landgren,Ola Landgren,Alexander M. Lesokhin,Alexander M. Lesokhin +22 more
TL;DR: The association between intestinal microbiota composition and treatment outcome in MM is reported and a higher relative abundance of Eubacterium hallii in the 16 MRD- patients relative to the 18 MRD+ patients is observed.
Immunophenotypic correlates of sustained MRD negativity in patients with multiple myeloma.
David C. Coffey,Francesco Lauria,Edgar Gonzalez-Kozlova,J. Javier Díaz-Mejía,Pingshan Luo,Yong Zhang,Yuexin Xu,Edus H. Warren,Travis Dawson,Brian Lee,Hui Xie,Eric Smith,Amanda Ciardiello,Hearn Jay Cho,Adeeb Rahman,Seunghee Kim-Schulze,Benjamin Diamond,Alexander M. Lesokhin,Dickran Kazandjian,Trevor J Pugh,D. Green,Sacha Gnjatic,Ola Landgren +22 more
TL;DR: It is observed that the composition of the immune microenvironment in both the blood and the marrow varied substantially according to both MRD negative status and history of autologous stem cell transplant, supporting the hypothesis that the immunemicroenvironment influences the depth and duration of treatment response.
P-162 Adding Plinabulin to pegfilgrastim to shorten neutropenia and improve quality of life peri-autologous hematopoietic cell transplant for multiple myeloma
Gunjan L. Shah,Danielle M Hanley,Ambika Datta,Alyssa Kamrowski,David Chung,Gaurav Gupta,Hani Hassoun,Elizabeth Hoover,Malin Hultcrantz,Neha Korde,Oscar B Lahoud,Heather Landau,Alexander M. Lesokhin,Sham Mailankody,Michael Scordo,Urvi A Shah,C. Tan,Saad Usmani,Lan Huang,Ramon Mohanlal,Sergio Giralt +20 more