Alexander A. Ishchenko
Université Paris-Saclay
93 Papers
883 Citations
Alexander A. Ishchenko is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: DNA glycosylase & Base excision repair. The author has an hindex of 28, co-authored 83 publications. Previous affiliations of Alexander A. Ishchenko include Russian Academy of Sciences & Institut Gustave Roussy.
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Papers
The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway
TL;DR: It is reported that Ape1, the major apurinic/apyrimidinic endonuclease in human cells, is the damage- specific endonUClease involved in NIR, and the kinetic constants indicate that APe1-catalysed NIR activity is highly efficient.
The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells
Anastasia Zlatanou,Emmanuelle Despras,Tirzah Braz-Petta,Imenne Boubakour-Azzouz,Caroline Pouvelle,Grant S. Stewart,Satoshi Nakajima,Akira Yasui,Alexander A. Ishchenko,Patricia Kannouche +9 more
TL;DR: It is shown that in response to oxidative stress, PCNA becomes transiently monoubiquitinated in an S phase- and USP1-independent manner and Polη interacts with mUb-PCNA at sites of oxidative DNA damage via its PCNA-binding and ubiquitin-binding motifs.
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Human DNA polymerase iota protects cells against oxidative stress.
Tirzah Braz Petta,Satoshi Nakajima,Anastasia Zlatanou,Emmanuelle Despras,Sophie Couvé-Privat,Alexander A. Ishchenko,Alain Sarasin,Akira Yasui,Patricia Kannouche +8 more
TL;DR: The data reveal a novel role of human polι in protecting cells from oxidative damage and green fluorescent protein‐tagged polι accumulates at the sites of oxidative DNA damage in living cells.
Enzymology of repair of etheno-adducts.
TL;DR: The fact that ethenoadducts are recognised and excised with high efficiency by various DNA glycosylases in vitro suggests that these enzymes may be responsible for repair of these mutagenic lesions in vivo, and thus constitute important contributors to genetic stability.
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A molecular beacon assay for measuring base excision repair activities.
Andrei Maksimenko,Alexander A. Ishchenko,Guenhael Sanz,Jacques Laval,Rhoderick H. Elder,Murat Saparbaev +5 more
TL;DR: This work introduces a direct method to assay DNA excision repair that is suitable for automation and industrial use, based on the fluorescence quenching mechanism of molecular beacons, and can be applied to all DNA modifications processed byDNA excision/incision repair pathways.
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