Alex P. Reiner

TL;DR: The novel loci will facilitate understanding the genetic aetiology of smoking behaviour and may lead to the identification of potential drug targets for smoking prevention and/or cessation.

TL;DR: This paper proposes the variant-set mixed model association tests (SMMAT) for continuous and binary traits using the generalized linear mixed model framework, and shows that all the proposed SMMATs correctly control type I error rates for both continuous andbinary traits in the presence of population structure and relatedness.

TL;DR: It is shown that a widely used two‐stage approach to genotype–phenotype associations can lead to tests with undesirable statistical properties, due to both combination of a mis‐specified mean–variance relationship and remaining covariate associations between the rank‐normalized residuals and genotypes.

TL;DR: A genome-wide association study of platelet count in 12,491 participants of the Hispanic Community Health Study/Study of Latinos by using a mixed-model method that accounts for admixture and family relationships underscores the value of diverse populations to extend insights into the allelic architecture of complex traits.