Alex Orme
University of Nottingham
7 Papers
255 Citations
Alex Orme is an academic researcher from University of Nottingham. The author has contributed to research in topics: SOX10 & SOX2. The author has an hindex of 7, co-authored 7 publications.
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Papers
Chick sox10, a transcription factor expressed in both early neural crest cells and central nervous system.
TL;DR: Cloned a chick Sox10 ortholog (cSox10) reveals a 1383 bp open reading frame encoding 461 amino acids which is highly conserved with human SOX10 and mouse Sox10 and is lost as cells undergo neuronal differentiation in ganglia of the peripheral nervous system.
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Differential expression of SOX4 and SOX11 in medulloblastoma.
TL;DR: The results suggest that strong Sox4 and Sox11 expression in classical medulloblastomas reflects their maturation-dependent expression during normal cerebellum development, and that they may therefore provide markers to divide tumors into clinically relevant subgroups.
120
CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons
Ching-Jung Lee,Wai-In Chan,Martin Cheung,Yi-Chuan Cheng,Vanessa J. Appleby,Alex Orme,Paul J. Scotting +6 more
TL;DR: The identification and characterization of a new gene, Cic, in both human and mouse genomes are described, which are orthologs of the Drosophila gene capicua, and represent a new subfamily of the HMG-box superfamily.
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cSox21 exhibits a complex and dynamic pattern of transcription during embryonic development of the chick central nervous system
TL;DR: The expression of cSox21, and other genes (such as Delta, Serrate and Pax genes), may play a part in defining the developmental fate of cells along the dorsoventral axis.
57
Sox8 gene expression identifies immature glial cells in developing cerebellum and cerebellar tumours
TL;DR: It is shown here that Sox8 is expressed in immature glia in the developing cerebellum, which provides an early glial marker that may provide more detailed insight into the cellular makeup and consequent behaviour of medulloblastomas.
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