6 Papers
121 Citations
Alex Hemeryck is an academic researcher from Johnson & Johnson Pharmaceutical Research and Development. The author has contributed to research in topics: Pharmacokinetics & NONMEM. The author has an hindex of 6, co-authored 6 publications.
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Papers
Tissue distribution and depletion kinetics of bortezomib and bortezomib-related radioactivity in male rats after single and repeated intravenous injection of 14 C-bortezomib.
Alex Hemeryck,Rita Geerts,Johan Monbaliu,Stephan Hassler,Tom Verhaeghe,Luc Diels,Willy L. M. Verluyten,Ludy van Beijsterveldt,Rao N. V. S. Mamidi,Cor G. M. Janssen,Roland De Coster +10 more
TL;DR: No undue tissue accumulation of TR and of bortezomib was observed in rats following a full clinical dosing cycle of bortsomib, and TR consisted almost exclusively of the parent drug.
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Mixed-effects modelling of the interspecies pharmacokinetic scaling of pegylated human erythropoietin.
TL;DR: The model predicted pharmacokinetics of PEG-EPO in humans suggest a less frequent dosing regimen relative to erythropoietin and darbepoetin, potentially leading to a simplification of anemia management.
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Pharmacokinetic Considerations and Efficacy of Levofloxacin in an Inhalational Anthrax (Postexposure) Rhesus Monkey Model
L. Mark Kao,Karen Bush,Roy E. Barnewall,James E. Estep,Frederic W. Thalacker,Pamela H. Olson,George L. Drusano,Neil Minton,Shuchean Chien,Alex Hemeryck,Kelley Michael F +10 more
TL;DR: It is demonstrated that a humanized dosing regimen of levofloxacin was effective in preventing morbidity and mortality from inhalational anthrax in rhesus monkeys and did not select for resistance.
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Population pharmacokinetic analysis of pegylated human erythropoietin in rats
TL;DR: The pharmacokinetics of PEG-EPO in the rat was successfully modeled using a two-compartmental model with a linear elimination from the central compartment and a first-order absorption process with lag time, and nonparametric bootstrap analysis confirmed the accuracy and the precision of the NONMEM parameter estimates.
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Pharmacokinetics, metabolism, excretion and plasma protein binding of 14C-levofloxacin after a single oral administration in the Rhesus monkey.
TL;DR: The present data indicated that the metabolism and excretion pattern, and also the in vitro plasma protein binding of levofloxacin in the Rhesus monkey, were comparable with those previously reported in man, hereby supporting the use of this animal species in the efficacy evaluation of lev ofl oxacin against inhalation anthrax.
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