Aletha B. Laurent
Oklahoma Medical Research Foundation
12 Papers
200 Citations
Aletha B. Laurent is an academic researcher from Oklahoma Medical Research Foundation. The author has contributed to research in topics: Adenosine deaminase deficiency & Adenosine deaminase. The author has an hindex of 9, co-authored 12 publications. Previous affiliations of Aletha B. Laurent include University of Oklahoma.
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Papers
Murine ecto-5'-nucleotidase (CD73): cDNA cloning and tissue distribution
Regina Resta,Scott W. Hooker,Karl R. Hansen,Aletha B. Laurent,J. L. Park,Michael R. Blackburn,Thomas B. Knudsen,Linda F. Thompson +7 more
TL;DR: Culture systems in which murine lymphocytes mature may be useful for examining the mechanisms of NT gene regulation, as well as the function of NT in the immune system.
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•Journal Article
Production and characterization of multiple antigenic peptide antibodies to the adenosine A2b receptor.
N K Puffinbarger,Karl R. Hansen,Regina Resta,Aletha B. Laurent,Thomas B. Knudsen,J L Madara,Linda F. Thompson +6 more
TL;DR: Cell type-specific patterns of expression are consistent with the hypothesized roles of the A2bR in mediating electrogenic Cl- secretion and the resulting secretory diarrhea caused by colonic crypt abscesses and in regulating morphogenesis of the placenta.
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CD73 expression and fyn‐dependent signaling on murine lymphocytes
Yoshio Yamashita,Scott W. Hooker,Hong Jiang,Aletha B. Laurent,Regina Resta,Regina Resta,Kamayani Khare,Andrew J. Coe,Paul W. Kincade,Linda F. Thompson +9 more
TL;DR: It is revealed that reticular and vascular cells throughout the thymus and other lymphoid tissues are markedly CD73+.
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Insights into thymic purine metabolism and adenosine deaminase deficiency revealed by transgenic mice overexpressing ecto-5'-nucleotidase (CD73).
Regina Resta,Scott W. Hooker,Aletha B. Laurent,S. M. Jamshedur Rahman,M Franklin,Thomas B. Knudsen,N L Nadon,Linda F. Thompson +7 more
TL;DR: Thymic adenosine concentrations of mice treated with the ADA inhibitor 2'-deoxycoformycin (dCF) were elevated over 30-fold, suggesting that high ADA activity, rather than an absence of 5'-NT, is mainly responsible for low thymicAdenosine levels.
•Journal Article
Glycosyl phosphatidylinositol membrane anchor is not required for T cell activation through CD73.
Regina Resta,Scott W. Hooker,Aletha B. Laurent,J K Shuck,Y Misumi,Y Ikehara,Gary A. Koretzky,Linda F. Thompson +7 more
TL;DR: CD73 transfectants of Jurkat mutants defective in the TCR, in p56lck, or in the tyrosine phosphatase CD45 did not secrete IL-2 in response to CD73 mAb + PMA, suggesting a role for the CD3/TCR-signaling complex in CD73-mediated signal transduction.
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