Alessio Papi
University of Bologna
34 Papers
180 Citations
Alessio Papi is an academic researcher from University of Bologna. The author has contributed to research in topics: Cell growth & Cancer cell. The author has an hindex of 16, co-authored 34 publications. Previous affiliations of Alessio Papi include University of Verona.
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Papers
Cytotoxic and antioxidant activity of 4-methylthio-3-butenyl isothiocyanate from Raphanus sativus L. (Kaiware Daikon) sprouts.
Alessio Papi,Marina Orlandi,Giovanna Bartolini,Jessica Barillari,Renato Iori,Moreno Paolini,Fiammetta Ferroni,Maria Grazia Fumo,Gian Franco Pedulli,Luca Valgimigli +9 more
TL;DR: It is demonstrated that GRH-ITC has interesting antioxidant/radical scavenging properties, associated with a selective cytotoxic/apoptotic activity toward three human colon carcinoma cell lines, and very limited toxicity on normal human T-lymphocytes.
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(-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line.
TL;DR: The present results showed that EGCG could down-regulate the activity of two molecules that play a key role in drug metabolism and transport and that are highly expressed in tamoxifen resistant breast carcinoma cells.
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(-)-Epigallocatechin-3-gallate down-regulates EGFR, MMP-2, MMP-9 and EMMPRIN and inhibits the invasion of MCF-7 tamoxifen-resistant cells.
TL;DR: EGCG could stop MCF-7Tam cell growth and in vitro invasion through down-regulation of EGFR and other molecules implicated in aggressive biological behaviour through EGCG treatment.
Kaiware Daikon (Raphanus sativus L.) extract: a naturally multipotent chemopreventive agent.
Jessica Barillari,Renato Iori,Alessio Papi,Marina Orlandi,Giovanna Bartolini,Simone Gabbanini,Gian Franco Pedulli,Luca Valgimigli +7 more
TL;DR: KDE administered in combination with myrosinase at doses corresponding to 50 microM GRH-ITC plus 15 microM GRE-ITCs to three human cancer cell lines significantly reduced cell growth by 94-96% of control in six days (p < 0.05), outperforming pure GRH/ GRE/KDE at the same dose, and the same treatment had no significant toxicity on normal human T-lymphocytes.
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EGFR inhibition by (-)-epigallocatechin-3-gallate and IIF treatments reduces breast cancer cell invasion.
TL;DR: The combination of EGCG and IIF significantly attenuated the invasive behaviour of breast carcinoma cells and altered the molecular network based on EGFR, CD44 and EMMPRIN expression interdependence.