Alessia Maddalena
University of Zurich
15 Papers
128 Citations
Alessia Maddalena is an academic researcher from University of Zurich. The author has contributed to research in topics: Alzheimer's disease & Tau protein. The author has an hindex of 12, co-authored 15 publications.
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Papers
Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer's Disease
Christoph Hock,Uwe Konietzko,Johannes Streffer,Jay Tracy,Andri Signorell,Britta Müller-Tillmanns,Ulrike Lemke,Katharina Henke,Eva Moritz,Esmeralda Garcia,M. Axel Wollmer,Daniel Umbricht,Dominique J.-F. de Quervain,Marc Hofmann,Alessia Maddalena,Andreas Papassotiropoulos,Roger M. Nitsch +16 more
TL;DR: It is established that antibodies against beta-amyloid plaques can slow cognitive decline in patients with Alzheimer's disease.
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Biochemical Diagnosis of Alzheimer Disease by Measuring the Cerebrospinal Fluid Ratio of Phosphorylated tau Protein to β-Amyloid Peptide42
Alessia Maddalena,Andreas Papassotiropoulos,Britta Müller-Tillmanns,Hans H. Jung,Thomas Hegi,Roger M. Nitsch,Christoph Hock +6 more
TL;DR: The diagnostic usefulness of the CSF ratio of phospho-tau to Abeta42 is superior to either measure alone and can be recommended as an aid to evaluating individuals suspected of having dementia.
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Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease.
Christoph Hock,Alessia Maddalena,Andreas Raschig,Franz Müller-Spahn,Gerhard W. Eschweiler,Klaus Hager,Isabella Heuser,Harald Hampel,Thomas Müller-Thomsen,Wolfgang H. Oertel,Marion Wienrich,Andri Signorell,Charo Gonzalez-Agosti,Roger M. Nitsch +13 more
TL;DR: Data show that treatment with the ml agonist talsaclidine reduced Aβ peptides, and particularly Aβ42, in AD patients, suggesting it as a potential amyloid lowering therapy of AD.
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Cerebrospinal fluid profile of amyloid beta peptides in patients with Alzheimer's disease determined by protein biochip technology.
Alessia Maddalena,Andreas Papassotiropoulos,Charo Gonzalez-Agosti,Andri Signorell,Thomas Hegi,Thomas Pasch,Roger M. Nitsch,Christoph Hock +7 more
TL;DR: Quantitation revealed that CSF levels of Aβ1–38 were significantly decreased in AD as compared to CTR subjects, and Aβ appeared to be a major Aβ species in human CSF along with Aβ1–40.
Fibroblasts can express glial fibrillary acidic protein (GFAP) in vivo
Johannes A. Hainfellner,Till Voigtländer,Thomas Ströbel,Peter R. Mazal,Alessia Maddalena,Adriano Aguzzi,Herbert Budka +6 more
TL;DR: It is concluded that human and murine fibroblasts can express GFAP in vivo, and the somatic distribution of GFAP expressing fibro Blasts indicates origin from the neural crest.