Alessia Bertozzi
6 Papers
1 Citations
Alessia Bertozzi is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 5 publications.
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Papers
Interleukin 1β triggers synaptic and memory deficits in Herpes simplex virus type-1-infected mice by downregulating the expression of synaptic plasticity-related genes via the epigenetic MeCP2/HDAC4 complex
Domenica Donatella Li Puma,Claudia Colussi,B. Bandiera,Giulia Puliatti,Marco Rinaudo,Sara Cocco,Fabiola Paciello,Agnese Re,Cristian Ripoli,Giovanna De Chiara,Alessia Bertozzi,Anna Teresa Palamara,Roberto Piacentini,Claudio Grassi +13 more
TL;DR: In this paper , the role of interleukin 1β (IL-1β), and the molecular cascade downstream the activation of its receptor, to the synaptic dysfunction occurring in the mouse model of multiple Herpes simplex virus type-1 (HSV-1) reactivations within the brain was investigated.
Activation of histamine type 2 receptors enhances intrinsic excitability of medium spiny neurons in the nucleus accumbens
Giuseppe Aceto,Luca Nardella,Simona Nanni,V Pecci,Alessia Bertozzi,Claudia Colussi,Marcello D'Ascenzo,Claudio Grassi +7 more
TL;DR: It is found that pharmacological activation of histamine 2 (H2) receptors elevates the excitability of NAc medium spiny neurons (MSNs), while activation of H1 receptors failed to significantly affect MSN excitability.
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Generation of an induced pluripotent stem cells line, CSSi014-A 9407, carrying the variant c.479C>T in the human iduronate 2-sulfatase (hIDS) gene.
Alessia Casamassa,Alessandra Zanetti,Daniela Ferrari,Ivan Lombardi,Gaia Galluzzi,Francesca D’Avanzo,Gabriella Cipressa,Alessia Bertozzi,Isabella Torrente,Angelo L. Vescovi,Rosella Tomanin,Jessica Rosati +11 more
TL;DR: In this paper , a line of induced pluripotent stem cells, generated from dermal fibroblasts, carrying the mutation c.479C>T, was obtained from a patient showing an attenuated phenotype.
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Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD
Claudia Colussi,Alessia Bertozzi,Lucia Leone,Marco Rinaudo,Raimondo Sollazzo,Federica Conte,Elena Paccosi,Luca Nardella,Giuseppe Aceto,Domenica Donatella Li Puma,Cristian Ripoli,M. G. Vita,Camillo Marra,Marcello D'Ascenzo,Claudio Grassi +14 more
TL;DR: Nucleoporin 153 deficiency in adult neural stem cells is linked to Alzheimer's disease pathology, characterized by defective neurogenesis, oxidative stress, and cognitive decline, and its recovery improves neurogenesis and cognitive function in a mouse model of AD.
Cytoplasmic HDAC4 recovers synaptic function in the 3×Tg mouse model of Alzheimer's disease
Claudia Colussi,Giuseppe Aceto,Cristian Ripoli,Alessia Bertozzi,Domenica Donatella Li Puma,E Paccosi,Marcello Dascenzo,Claudio Grassi +7 more
TL;DR: In this article , the authors investigated how the modulation of HDAC4 may contribute to counteracting Alzheimer's disease pathogenesis and found that it was a crucial factor in shaping synaptic plasticity and memory.