Alessandra Galati
Sapienza University of Rome
12 Papers
36 Citations
Alessandra Galati is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Telomere & Telomere-binding protein. The author has an hindex of 10, co-authored 11 publications. Previous affiliations of Alessandra Galati include École normale supérieure de Lyon & Laboratory of Molecular Biology.
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Papers
Chromatin Structure in Telomere Dynamics
TL;DR: Recent findings on chromatin modifications associated with the dynamic changes of telomeres from protected to deprotected state and their role in telomere functions are reviewed.
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AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance
Romina Burla,Mariateresa Carcuro,Grazia D. Raffa,Alessandra Galati,Domenico Raimondo,Angela Maria Rizzo,Mattia La Torre,Emanuela Micheli,Laura Ciapponi,Giovanni Cenci,Enrico Cundari,Antonio Musio,Annamaria Biroccio,Stefano Cacchione,Maurizio Gatti,Isabella Saggio +15 more
TL;DR: It is suggested that AKTIP/Ft1 works in concert with TRF1 to facilitate telomeric DNA replication, a novel mammalian shelterin-bound factor identified on the basis of its homology with the Drosophila telomere protein Pendolino.
TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization
Alessandra Galati,Emanuela Micheli,Claudia Alicata,Tiziano Ingegnere,Alessandro Cicconi,Miriam Caroline Pusch,Marie Josèphe Giraud-Panis,Eric Gilson,Stefano Cacchione +8 more
TL;DR: The results indicate that the different behavior of TRF proteins partly depends on the interaction with histone tails of their divergent N-terminal domains, and it is proposed that the interplay between the histone octamer and TRf proteins plays a role in the steps leading to telomere deprotection.
Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation
Lu Chen,Caitlin M. Roake,Alessandra Galati,Francesca Bavasso,Emanuela Micheli,Isabella Saggio,Stefan Schoeftner,Stefano Cacchione,Maurizio Gatti,Steven E. Artandi,Grazia D. Raffa +10 more
TL;DR: It is shown that depletion of trimethylguanosine synthase 1 (TGS1), the enzyme responsible for cap hypermethylation, increases levels of hTR and telomerase, and limits telomere elongation in cultured human cells.
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The Human Telomeric Protein TRF1 Specifically Recognizes Nucleosomal Binding Sites and Alters Nucleosome Structure
Alessandra Galati,Luigi Rossetti,Sabrina Pisano,Lynda Chapman,Daniela Rhodes,Maria Savino,Stefano Cacchione +6 more
TL;DR: It is shown that TRF1 is able to specifically recognize telomeric binding sites located within nucleosomes, forming a ternary complex that contributes to the establishment of a telomere capping complex, whose structure and dynamics can be modulated by the binding of telomersic factors.
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