Alessandra Folci
Centre national de la recherche scientifique
5 Papers
Alessandra Folci is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: SUMO protein & Dendritic spine. The author has an hindex of 5, co-authored 5 publications.
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Papers
Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice.
Marta Prieto,Alessandra Folci,Gwénola Poupon,Sara Schiavi,Valeria Buzzelli,Marie Pronot,Urielle François,Paula A. Pousinha,N. Lattuada,Sophie Abelanet,Sara Castagnola,Magda Chafai,Anouar Khayachi,Carole Gwizdek,Frédéric Brau,Emmanuel Deval,Maura Francolini,Barbara Bardoni,Yann Humeau,Viviana Trezza,Stéphane Martin +20 more
TL;DR: In this paper, a knock-in mouse model expressing the FMRP-R138Q protein was generated to investigate the mechanisms underlying Fragile X syndrome caused by this mutation, and they demonstrated that neurons show an increased spine density associated with synaptic ultrastructural defects and increased AMPA receptor surface expression.
Post-translational modifications of the Fragile X Mental Retardation Protein in neuronal function and dysfunction.
TL;DR: The possibility that recently reported missense mutations in the FMR1 gene disrupt the PTM homoeostasis of FMRP, thus participating in the aetiology of FXS is explored.
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Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation
Anouar Khayachi,Carole Gwizdek,Gwénola Poupon,Damien Alcor,Magda Chafai,Frédéric Cassé,Thomas Maurin,Marta Prieto,Alessandra Folci,Fabienne De Graeve,Sara Castagnola,Romain Gautier,Lenka Schorova,Céline Loriol,Marie Pronot,Florence Besse,Frédéric Brau,Emmanuel Deval,Barbara Bardoni,Stéphane Martin +19 more
TL;DR: It is shown that FMRP sumoylation is required for regulating spine density and maturation, and is revealed as a critical activity-dependent regulatory mechanism of F MRP-mediated neuronal function.
The synaptic balance between sumoylation and desumoylation is maintained by the activation of metabotropic mGlu5 receptors.
Lenka Schorova,Marie Pronot,Gwénola Poupon,Marta Prieto,Alessandra Folci,Anouar Khayachi,Frédéric Brau,Frédéric Cassé,Carole Gwizdek,Stéphane Martin +9 more
TL;DR: The mGlu5R system is revealed as a central activity-dependent mechanism to maintaining the homeostasis of sumoylation at the mammalian synapse and the resulting post-synaptic accumulation of SENP1 restores synaptic sumoylated to initial levels.
New Insights Into the Role of Cav2 Protein Family in Calcium Flux Deregulation in Fmr1-KO Neurons.
Sara Castagnola,Sébastien Delhaye,Alessandra Folci,Agnès Paquet,Frédéric Brau,Fabrice Duprat,Marielle Jarjat,Mauro Grossi,Méline Béal,Stéphane Martin,Massimo Mantegazza,Barbara Bardoni,Thomas Maurin +12 more
TL;DR: A new phenotype of cultured Fmr1-KO neurons is highlighted that can be considered a novel cellular biomarker and is amenable to small molecule screening and identification of new drugs to treat FXS.