Alenka Chapron
University of Washington
8 Papers
20 Citations
Alenka Chapron is an academic researcher from University of Washington. The author has contributed to research in topics: Kidney disease & Kidney. The author has an hindex of 5, co-authored 8 publications.
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Papers
Development of a microphysiological model of human kidney proximal tubule function
Elijah J. Weber,Alenka Chapron,Brian D. Chapron,Jenna L. Voellinger,Kevin A. Lidberg,Catherine K. Yeung,Zhican Wang,Yoshiyuki Yamaura,Dale W. Hailey,Thomas Neumann,Danny D. Shen,Kenneth E. Thummel,Kimberly A. Muczynski,Jonathan Himmelfarb,Edward J. Kelly +14 more
TL;DR: This microphysiological system can serve as an ideal platform for ex vivo modeling of renal drug clearance and drug-induced nephrotoxicity and can be used for preclinical screening of new chemical compounds prior to initiating human clinical trials.
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Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity
Shih-Yu Chang,Elijah J. Weber,Viktoriya S. Sidorenko,Alenka Chapron,Catherine K. Yeung,Chunying Gao,Qingcheng Mao,Danny D. Shen,Joanne Wang,Thomas A. Rosenquist,Kathleen G. Dickman,Thomas Neumann,Arthur P. Grollman,Edward J. Kelly,Jonathan Himmelfarb,David L. Eaton +15 more
TL;DR: It is demonstrated that human hepatocyte-specific metabolism of AA-I substantially increases its cytotoxicity toward human kidney proximal tubular epithelial cells, including formation of aristolactam adducts and release of kidney injury biomarkers.
Does Secretory Clearance Follow Glomerular Filtration Rate in Chronic Kidney Diseases? Reconsidering the Intact Nephron Hypothesis.
Alenka Chapron,Danny D. Shen,Bryan Kestenbaum,Cassianne Robinson-Cohen,Jonathan Himmelfarb,Catherine K. Yeung +5 more
TL;DR: Dosing adjustments in CKD require refinement; in addition to GFR, biomarkers of tubular function are needed for secreted drugs, and failure of GFR to predict changes in secretory clearance is indicated.
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An Improved Vascularized, Dual-Channel Microphysiological System Facilitates Modeling of Proximal Tubular Solute Secretion
Alenka Chapron,Brian D. Chapron,Dale W. Hailey,Shih-Yu Chang,Tomoki Imaoka,Kenneth E. Thummel,Edward J. Kelly,Jonathan Himmelfarb,Danny D. Shen,Catherine K. Yeung +9 more
- 28 Jan 2020
TL;DR: The VPT-MPS holds the promise of providing an in vitro platform for evaluating the renal secretion of new drug candidates and investigating the dysregulation of tubular drug secretion in chronic kidney disease.
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Bridging the gap between in silico and in vivo by modeling opioid disposition in a kidney proximal tubule microphysiological system.
Tomoki Imaoka,Weize Huang,Sara Shum,Dale W. Hailey,Dale W. Hailey,Shih-Yu Chang,Alenka Chapron,Catherine K. Yeung,Jonathan Himmelfarb,Nina Isoherranen,Edward J. Kelly +10 more
TL;DR: In this article, a vascularized human proximal tubule microphysiological system (VPT-MPS) coupled with a parent-metabolite full body physiologically-based pharmacokinetic (PBPK) model was used to predict renal clearance and systemic disposition of morphine and its active metabolite morphine-6-glucuronide (M6G) in CKD patients.
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