Alberto Leoni
University of Bologna
120 Papers
1K Citations
Alberto Leoni is an academic researcher from University of Bologna. The author has contributed to research in topics: Thiazole & Chemistry. The author has an hindex of 30, co-authored 117 publications. Previous affiliations of Alberto Leoni include Molecular and Behavioral Neuroscience Institute & University of Ferrara.
Chat about Author
Papers
Synthesis and antitubercular activity of imidazo[2,1-b]thiazoles
Aldo Andreani,Massimiliano Granaiola,Alberto Leoni,Alessandra Locatelli,Rita Morigi,Mirella Rambaldi +5 more
TL;DR: A number of selected imidazo[2,1-b]thiazoles entered the screening at the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) and one of these compounds, 2-chloro-6-phenylimidazole, showed antitubercular activity, which planned the synthesis of new analogues bearing a substituted ring at the 6 position.
150
New isatin derivatives with antioxidant activity.
Aldo Andreani,Silvia Burnelli,Massimiliano Granaiola,Alberto Leoni,Alessandra Locatelli,Rita Morigi,Mirella Rambaldi,Lucilla Varoli,Mauro Andrea Cremonini,Giuseppe Placucci,Rinaldo Cervellati,Emanuela Greco +11 more
TL;DR: Three published antitumor agents showed a good chemical antioxidant activity and the main product was identified as 3,3-bis(4-amino-2,5-dimethoxyphenyl)-1-3-dihydroindol-2-one.
116
Potential antitumor agents. part 291: synthesis and potential coanthracyclinic activity of Imidazo[2,1-b]thiazole guanylhydrazones
Aldo Andreani,Alberto Leoni,Alessandra Locatelli,Rita Morigi,Mirella Rambaldi,Maurizio Recanatini,Vida Garaliene +6 more
TL;DR: The synthesis of new imidazo[2,1-b]thiazole guanylhydrazones which were tested as potential antitumor agents and three of these derivatives were the most potent and one of these showed a mild effect as CDK1 inhibitor.
79
Potential antitumor agents. 37. Synthesis and antitumor activity of guanylhydrazones from imidazo[2,1-b]thiazoles and from the new heterocyclic system thiazolo[2',3':2,3]imidazo[4,5-c]quinoline
Aldo Andreani,Massimiliano Granaiola,Alberto Leoni,Alessandra Locatelli,Rita Morigi,Mirella Rambaldi,Giorgio Lenaz,Romana Fato,Christian Bergamini,Giovanna Farruggia +9 more
TL;DR: The effect of the guanylhydrazone of 2-chloro-6-(2,5-dimethoxy-4-nitrophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde was investigated, and it was found to be an inhibitor of Complex III of the mitochondrial respiratory chain and is able to induce apoptosis in the cell lines HT29 and HL60.
75
Antitumor activity of new substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and 3-(5-imidazo[2,1-b]thiadiazolylmethylene)-2-indolinones: selectivity against colon tumor cells and effect on cell cycle-related events.
Aldo Andreani,Silvia Burnelli,Massimiliano Granaiola,Alberto Leoni,Alessandra Locatelli,Rita Morigi,Mirella Rambaldi,Lucilla Varoli,Natalia Calonghi,Concettina Cappadone,Manuela Voltattorni,Maddalena Zini,Claudio Stefanelli,Lanfranco Masotti,Robert H. Shoemaker +14 more
TL;DR: Its ability to inhibit cellular proliferation was mediated by cell cycle arrest at the G2/M phase, accompanied by inhibition of ornithine decarboxylase (ODC), the limiting enzyme of polyamine synthesis, and followed by induction of apoptosis.
74