Alberto Elosegui-Artola

TL;DR: Two different computational tools are designed to quantify actin SFs and the distribution of actin cytoskeletal proteins within a normalized cellular morphology and provide a better insight into the cell mechanics and broadens the knowledge of the nature of SFs.

TL;DR: It is demonstrated that the nano/microstructural morphological cues of the scaffolds, e.g. nanoporosity of fibers and fiber density and thus porosity, plays a key role in possible targets to regulate cell behaviors, suggesting that well-tailored electrospun scaffolds with desired composition and Fiber density are required for a potential means for application in tissue engineering.

TL;DR: It is suggested that, in patients with severe aortic stenosis with preserved ejection fraction and symptoms of heart failure, diastolic dysfunction is associated with increased nonmysial deposition of collagen, predominantly type I, resulting in increased extracellular matrix stiffness.

TL;DR: It is described that loss of the integrin inhibitor, SHARPIN, impedes MSF spreading specifically on soft type I collagen but not on fibronectin, and α11β1 play a role in collagen-specific mechanosensing in MSFs.