Albert To

TL;DR: In this article, the authors described the production of insect-cell expressed SARS-CoV-2 spike protein ectodomain constructs and examined their immunogenicity in mice, and demonstrated that, when formulated with CoVaccine HTTM adjuvant, an oil-in-water nanoemulsion compatible with lyophilization, their vaccine candidates elicit a broad-spectrum IgG response, high neutralizing antibody (NtAb) titers against SARS CoV2 prototype and variants of concern, specifically B.1.351 (Beta) and

TL;DR: In this paper, the authors described the production of insect-cell expressed SARS-CoV-2 spike protein ectodomain and examined its immunogenicity in mice, and demonstrated that, when formulated with CoVaccine HT™adjuvant, an oil-in-water nanoemulsion compatible with lyophilization, their vaccine candidates elicit a broad-spectrum IgG response, high neutralizing antibody titers, and a robust, antigen-specific IFN-γ secreting response from immune splenocytes in outbred mice.

TL;DR: In this paper, the development and characterization of monovalent and trivalent filovirus vaccines that are co-lyophilized with a squalane-in-water emulsion adjuvant was described.

TL;DR: Monovalent subunit vaccines consisting of glycoproteins from EBOV, MARV, and SUDV were stabilized within amorphous disaccharide glasses through lyophilization to improve the thermostability of filovirus vaccines in order to potentially relax or eliminate these cold-chain requirements.