Albert Kwok
University of Cambridge
14 Papers
65 Citations
Albert Kwok is an academic researcher from University of Cambridge. The author has contributed to research in topics: Transfection & Small interfering RNA. The author has an hindex of 10, co-authored 14 publications. Previous affiliations of Albert Kwok include University College London & National Institute for Health Research.
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Papers
Comparative structural and functional studies of nanoparticle formulations for DNA and siRNA delivery.
TL;DR: Comparisons of branched versus linear cationic polymers, i.e, polyethylenimine (PEI) and 22-kDa linear PEI with both DNA and small interfering RNA were compared for their formation of condensed DNA and SiRNA complexes to highlight the importance of particle stability for efficient siRNA and plasmid delivery.
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Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations
Isabel Huang-Doran,Patsy Tomlinson,Patsy Tomlinson,Felicity Payne,Alexandra Gast,Alexandra Gast,Alison Sleigh,William Bottomley,Julie Harris,Julie Harris,Allan Daly,Nuno Rocha,Nuno Rocha,Simon A. Rudge,Jonathan Clark,Albert Kwok,Albert Kwok,Stefano Romeo,Emma McCann,Barbara Müksch,Mehul T. Dattani,Stefano Zucchini,Michael J.O. Wakelam,Lazaros C. Foukas,David B. Savage,David B. Savage,Rinki Murphy,Stephen O'Rahilly,Stephen O'Rahilly,Inês Barroso,Inês Barroso,Inês Barroso,Robert K. Semple,Robert K. Semple +33 more
TL;DR: PIK3R1 C-terminal mutations impair insulin signaling only in some cellular contexts and produce a subphenotype of insulin resistance resembling INSR dysfunction but unlike AKT2 dysfunction, implicating PI3K in the pathogenesis of key components of the metabolic syndrome.
Integrin-targeted nanocomplexes for tumour specific delivery and therapy by systemic administration.
Aristides D. Tagalakis,Stephanie M. Grosse,Qing-Hai Meng,M. Firouz Mohd Mustapa,Albert Kwok,Shahla E Salehi,Alethea B. Tabor,Helen C. Hailes,Stephen L. Hart +8 more
TL;DR: Transfection in tumours was enhanced two-fold by integrin-targeting peptides compared to non-targeted nanocomplexes, which may have broader applications in the further development of cancer therapeutics.
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Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure
Albert Kwok,Ilona Zvetkova,Samuel Virtue,Ineke Luijten,Isabel Huang-Doran,Patsy Tomlinson,David A Bulger,James A. West,Steven A. Murfitt,Julian L. Griffin,Rafeah Alam,Daniel Hart,Rachel G. Knox,Peter J. Voshol,Antonio Vidal-Puig,Jørgen Arendt Jensen,Stephen O'Rahilly,Robert K. Semple,Robert K. Semple,Robert K. Semple +19 more
TL;DR: Pik3r1 dysfunction in mice phenocopies the IR and reduced adiposity may not reflect bona fide lipodystrophy, but rather, increased energy expenditure, and it is suggested that further study of brown adipose tissue in both humans and mice is warranted.
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Peptide Dendrimer-Lipid Conjugates as DNA and siRNA Transfection Reagents: Role of Charge Distribution Across Generations.
Marc Heitz,Albert Kwok,Gabriela A. Eggimann,Florian Hollfelder,Tamis Darbre,Jean-Louis Reymond +5 more
TL;DR: This work has developed a new class of well-defined and easily modifiable transfection reagents in the form of peptide dendrimers which self-assemble with DNA or siRNA and lipofectin to form nanoparticles which efficiently enter mammalian cells and liberate their nucleic acid cargo.
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