Albert Grass
10 Papers
Albert Grass is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 1, co-authored 5 publications.
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Papers
Homologous recombination deficiency (HRD) as an ovarian cancer biomarker in a real-world cohort - validation of decentralized genomic profiling.
Carsten Denkert,Marcel Romey,Bradley D. Swedlund,Akira Hattesohl,Julia Teply-Szymanski,Stefan Kommoss,Kristine A. Kaiser,Annette Staebler,Andreas du Bois,Albert Grass,Christiane Knappmeyer,Florian Heitz,Cara Solimeno,T Ebel,Philipp Harter,Frederik Marmé,Paul Jank,Timo Gaiser,Chris Neff,Uwe Wagner,Kirsten Timms,Fiona R. Rodepeter +21 more
TL;DR: In this article , the authors evaluated homologous recombination deficiency (HRD) in 514 ovarian carcinoma samples by next-generation sequencing of DNA libraries, including BRCA1/BRCA2 and 26,523 single nucleotide polymorphisms using the standardized Myriad HRD assay, with the predefined cut point of ≥42 for a positive genomic instability score (GIS).
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pT3 colorectal cancer revisited: a multicentric study on the histological depth of invasion in more than 1000 pT3 carcinomas—proposal for a new pT3a/pT3b subclassification
Sebastian Foersch,Corinna Lang-Schwarz,Markus Eckstein,Carol Geppert,Maxime Schmitt,Björn Konukiewitz,T. Groll,Felix Schicktanz,Jutta Engel,M. Gleitsmann,Christina C. Westhoff,Nadine Frickel,Anne Sophie Litmeyer,Albert Grass,Paul Jank,Sebastian Lange,Markus Tschurtschenthaler,Dirk Wilhelm,Wilfried Roth,Michael Vieth,Carsten Denkert,Iris D. Nagtegaal,Wilko Weichert,Moritz Jesinghaus +23 more
TL;DR: The histological depth of invasion into the pericolic/perirectal fat was digitally and conventionally measured in a training cohort of 950 colorectal carcinoma (CRC) patients as discussed by the authors .
Frequency and Prognostic Significance of Intertumoural Heterogeneity in Multifocal Jejunoileal Neuroendocrine Tumours
Moritz Jesinghaus,Jelte Poppinga,Bettina J. Lehman,Elisabeth Maurer,Annette Ramaswamy,Albert Grass,Pietro Di Fazio,Anja Rinke,Carsten Denkert,Detlef K. Bartsch +9 more
TL;DR: Although multifocal SI-NET showed some degree of heterogeneity in their central morphological parameters, these findings do not appear to be of major clinical significance, rendering an extensive testing of all multifocal lesions as not necessarily required, and neither heterogeneity of any of the aforementioned markers nor multifocality itself had any impact on patient survival.
Systematic analysis of HRD testing in ovarian cancer - development of recommendations for optimal assay performance.
Marcel Romey,Fiona Rodepeter,Akira Hattesohl,Kristin Kaiser,Julia Teply-Szymanski,Florian Heitz,A. Staebler,Violeta Serra,Albert Grass,Frederik Marmé,Kirsten M. Timms,Philip Harter,Alba Llop-Guevara,Stefan Kommoss,Jelena Boekhoff,Carsten Denkert +15 more
TL;DR: Based on a systematic analysis of tumor cell content and tumor area, patient high-grade serous ovarian cancer samples that display a tumor cell content ≥30% and a tumor area ≥0.5 cm2 are recommended for HRD testing, to allow for optimal chances of a successful analysis and conclusive results.
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PITX2 as a Sensitive and Specific Marker of Midgut Neuroendocrine Tumors: Results from a Cohort of 1157 Primary Neuroendocrine Neoplasms.
Albert Grass,A. Kasajima,Sebastian Foersch,Mark Kriegsmann,Alexander Brobeil,Maxime Schmitt,Daniel Wagner,Jelte Poppinga,Dominik Wiese,Elisabeth Maurer,Andreas Kirschbaum,Thomas Muley,H. Winter,Anja Rinke,Thomas M. Gress,Markus Kremer,Matthias Evert,Bruno Märkl,A. Quaas,Markus Eckstein,Markus Tschurtschenthaler,Günter Klöppel,Carsten Denkert,Detlef K Bartsch,Moritz Jesinghaus +24 more
TL;DR: PITX2 is independently validates as a very sensitive and specific immunohistochemical marker of midgut-derived NET in a very large collective of Neuroendocrine Neoplasms and argues towards implementation into diagnostic panels applied for NET as a first line midgut marker.
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