Albert A. Yen
Houston Methodist Hospital
24 Papers
108 Citations
Albert A. Yen is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Population. The author has an hindex of 15, co-authored 23 publications. Previous affiliations of Albert A. Yen include Baylor College of Medicine.
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Papers
Forced vital capacity (FVC) as an indicator of survival and disease progression in an ALS clinic population
TL;DR: It is concluded that a single FVC value obtained at an initial visit may serve as a clinically meaningful predictor of survival and disease progression in ALS.
Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia.
Qin Xiao,Weihua Zhao,David R. Beers,Albert A. Yen,Wenjie Xie,Jenny S. Henkel,Stanley H. Appel +6 more
TL;DR: Microglia over‐expressing mutant human superoxide dismutase (mSOD1G93A) may contribute to motoneuron death in a transgenic mouse model of familial amyotrophic lateral sclerosis and induced more mot oneuron injury than similarly treated wild‐type microglia.
174
Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism.
Weihua Zhao,Wenjie Xie,Weidong Le,David R. Beers,Yi He,Jenny S. Henkel,Ericka Simpson,Albert A. Yen,Qin Xiao,Stanley H. Appel +9 more
TL;DR: It is suggested that free radicals released from activated microglia may initiate motor neuron injury by increasing the susceptibility of the MN AMPA/kainate receptor to the toxic effects of glutamate.
Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson’s disease
Ira L. Goldknopf,Essam A. Sheta,Jennifer K. Bryson,Brian Folsom,Chris Wilson,Jeff Duty,Albert A. Yen,Stanley H. Appel +7 more
TL;DR: Differences in abnormal serum levels were found between amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and related disorders for 34 protein biomarker spots, nine of which were related to the complement system.
136
Oxidative Stress: a common denominator in the pathogenesis of amyotrophic lateral sclerosis.
TL;DR: The clinical aspects of amyotrophic lateral sclerosis and potential mechanisms of disease pathogenesis are reviewed in the context of recent data supporting a major role for oxidative stress throughout the disease course.
114