Alastair J. Florence
Strathclyde Institute of Pharmacy and Biomedical Sciences
194 Papers
1.2K Citations
Alastair J. Florence is an academic researcher from Strathclyde Institute of Pharmacy and Biomedical Sciences. The author has contributed to research in topics: Crystal structure & Crystallization. The author has an hindex of 36, co-authored 180 publications. Previous affiliations of Alastair J. Florence include Engineering and Physical Sciences Research Council & University of Strathclyde.
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Papers
Crystal morphology of ibuprofen predicted from single-crystal pulsed neutron diffraction data
Norman Shankland,Alastair J. Florence,Philip J. Cox,David B. Sheen,Steve W. Love,Neil S. Stewart,Chick C. Wilson +6 more
TL;DR: In this paper, a pulsed neutron diffraction was used to determine accurate positions and thermal parameters for all 33 atoms of the ibuprofen molecule, and the data used to predict the crystal morphology.
Drug solid solutions – a method for tuning phase transformations
Amit Delori,Pauline Maclure,Rajni M. Bhardwaj,Andrea Johnston,Alastair J. Florence,Oliver B. Sutcliffe,Iain D. H. Oswald +6 more
TL;DR: In this paper, a methodology for the modification of phase transition temperatures using (±)-4′-methylmethcathinone solid solutions as an exemplar is described. But this method does not consider the effect of the halide ion on phase transition temperature.
Targeted crystallisation of novel carbamazepine solvates based on a retrospective Random Forest classification
TL;DR: In this article, the antiepileptic compound carbamazepine was obtained by targeted crystallisation from solvents identified by a Random Forest classification of solvent properties, experimental conditions and known crystallisation outcomes.
Mesoscopic Solute-Rich Clusters in Olanzapine Solutions
TL;DR: In this paper, the authors demonstrate the existence of mesoscopic solute-rich clusters in undersaturated OZPN solutions in purely aqueous and mixed EtOH/aqueous solvents.
Successful Computationally Directed Templating of Metastable Pharmaceutical Polymorphs
David H. Case,Vijay Srirambhatla,Rui Guo,Rona E. Watson,Louise S. Price,Hector Polyzois,Jeremy K. Cockcroft,Alastair J. Florence,Derek A. Tocher,Sarah L. Price +9 more
TL;DR: In this article, a strategy of using crystal structure prediction (CSP) methods to determine which, if any, isostructural template could facilitate the first crystallization of a predicted polymorph by vapor deposition is extended to the fenamate family.