Alastair J. Florence
Strathclyde Institute of Pharmacy and Biomedical Sciences
194 Papers
1.2K Citations
Alastair J. Florence is an academic researcher from Strathclyde Institute of Pharmacy and Biomedical Sciences. The author has contributed to research in topics: Crystal structure & Crystallization. The author has an hindex of 36, co-authored 180 publications. Previous affiliations of Alastair J. Florence include Engineering and Physical Sciences Research Council & University of Strathclyde.
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Papers
Abstract - The current study aims to establish an innovative method of effectively solubilising Biopharmaceutical Classification System Class II drugs using inkjet printing. Dosage forms have been produced using an Optomec AJ200 3D Inkjet printer. Printing with an appropriate polymer seems to result in an amorphous product, which will hopefully have a greater overall solubility.
Alice J. Turner,Gavin Halbert,Alastair J. Florence +2 more
- 01 Jan 2015
10,11-dihydrocarbamazepine-form-amide solvate (1/1)
TL;DR: In this article, the dihydrocarbamazepine and formamide molecules are hydrogen bonded to form an R-2(2)(8) dimer, which is further connected to form a ladder motif.
Developing process understanding for continuous manufacturing of Lamivudine (Epivir®) Stable Form I
Ebenezer Ojo,Zied Hosni,Iyke I. Onyemelukwe,Lennart A. I. Ramakers,Ian Houson,Alastair J. Florence +5 more
- 09 Jul 2019
TL;DR: The key research question here is to Translate current batch crystallisation into a continuous process to improve the downstream process-ability by modifying the particle properties and develop miniaturise platforms for accelerated process development.
The role of in-line image analysis in the transition to continuous manufacturing in the pharmaceutical industry
Javier Cardona,Carla Ferreira,Vaclav Svoboda,Bilal Ahmed,John McGinty,Okpeafoh S. Agimelen,Andrew Hamilton,Alison Cleary,Robert Atkinson,Craig Michie,Stephen Marshall,Alastair J. Florence,Yi-Chieh Chen,Jan Sefcik,Ivan Andonovic,Christos Tachtatzis +15 more
- 11 Sep 2018
TL;DR: This work presents an image analysis framework developed to address one of the main challenges of in-line image analysis: the presence of out-of-focus particles.
Inkjet printing scalable dosage forms capable of increasing the solubility of BCS Class II drugs
Alice J. Turner,Gavin Halbert,Alastair J. Florence +2 more
- 15 Nov 2017
TL;DR: In this article, the authors used inkjet printing to increase the solubility of poorly soluble drugs using a view to creating formulations which are more easily tailored to the needs of the patient, and showed that printing the BCS Class II drugs alone results in a crystalline product but on addition of a polymer this crystallinity is reduced and it is possible to print solid dispersions which are fully amorphous.