Alan R. Battersby
University of Cambridge
293 Papers
3.9K Citations
Alan R. Battersby is an academic researcher from University of Cambridge. The author has contributed to research in topics: Porphobilinogen & Porphyrin. The author has an hindex of 33, co-authored 293 publications. Previous affiliations of Alan R. Battersby include University of Canterbury.
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Papers
Biosynthesis of porphyrins and related macrocycles. Part 25. Synthesis of analogues of coproporphyrinogen-III and studies of their interaction with coproporphyrinogen-III oxidase from Euglena gracilis
TL;DR: Conditions have been defined for the MacDonald synthesis of porphyrins which yield products of high isomeric purity.
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Synthesis relevant to vitamin B12 biosynthesis: synthesis of (±)Faktor-I octamethyl ester
TL;DR: Faktor-I, the chlorin which arises by aromatisation of the mono-C-methylated intermediate on the biosynthetic pathway to vitamin B12, has been synthesized in racemic form as its octamethyl ester by ring-closing the macrocycle photochemically as discussed by the authors.
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Biosynthesis of porphyrins and related macrocycles. Part 9. Biosynthesis of the corrin macrocycle of vitamin B12 including the stereochemistry of C-methylation in ring c
TL;DR: Investigation of the biosynthesis of vitamin B12 using carbon-13 labelling coupled with n.r.m. spectroscopy with Propionibacterium Shermanii shows that the corrin macrocycle is constructed from eight molecules of 5-aminolaevulinic acid and seven methyl groups derived from methionine.
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X-Ray determination of the structure of OO-dimethylipecoside
Olga Kennard,Paul J. Roberts,N. W. Isaacs,Frank H. Allen,W. D. S. Motherwell,K. H. Gibson,Alan R. Battersby +6 more
TL;DR: The structure and stereochemistry of OO-dimethylipecoside have been shown by direct X-ray analysis of the sesquihydrate as mentioned in this paper, which is the most common OO derivative.
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The biosynthesis of narciclasine
TL;DR: Tracer experiments prove that the antimitotic agent narciclasine is biosynthesised from O-methyl-norbelladine by para–para coupling followed by late elimination of two carbon atoms.
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