Alan M. Race
National Physical Laboratory
30 Papers
86 Citations
Alan M. Race is an academic researcher from National Physical Laboratory. The author has contributed to research in topics: Mass spectrometry imaging & Chemistry. The author has an hindex of 13, co-authored 24 publications. Previous affiliations of Alan M. Race include AstraZeneca & University of Bayreuth.
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Papers
Inclusive sharing of mass spectrometry imaging data requires a converter for all.
TL;DR: It is proposed that proprietary formats should first be converted to mzML using one of the widely available converters, such as msconvert and then use imzMLConverter to convert mZML to imz ML, which will allow a wider audience to benefit from the imZML format immediately.
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The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer.
Arafath Kaja Najumudeen,Fatih Ceteci,Sigrid K. Fey,Gregory Hamm,Rory T. Steven,Holly Hall,Chelsea J. Nikula,Alex Dexter,Teresa Murta,Alan M. Race,Alan M. Race,David Sumpton,Nikola Vlahov,John R. P. Knight,Rene Jackstadt,Joshua D.G. Leach,Rachel A. Ridgway,Emma R. Johnson,Colin Nixon,Ann Hedley,Kathryn Gilroy,William C. Clark,Sudhir B Malla,Philip D Dunne,Giovanny Rodriguez-Blanco,Susan E. Critchlow,Agata Mrowinska,Gaurav Malviya,Dmitry Solovyev,Gavin Brown,David Y. Lewis,Gillian M. Mackay,Douglas Strathdee,Saverio Tardito,Eyal Gottlieb,Zoltan Takats,Simon T. Barry,Richard J. A. Goodwin,Richard J. A. Goodwin,Josephine Bunch,Martin Bushell,Andrew D. Campbell,Owen J. Sansom +42 more
TL;DR: In this article, SLC7A5 maintains intracellular amino acid levels following KRAS activation through transcriptional and metabolic reprogramming, which supports the increased demand for bulk protein synthesis that underpins the enhanced proliferation of KRAS-mutant cells.
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LESA FAIMS Mass Spectrometry for the Spatial Profiling of Proteins from Tissue
Rian L. Griffiths,Andrew J. Creese,Alan M. Race,Josephine Bunch,Josephine Bunch,Helen J. Cooper +5 more
TL;DR: The results show that the number of different protein species detected can be significantly increased by incorporating FAIMS into the workflow and the spatial distributions of proteins identified were in good agreement indicating thatFAIMS is a suitable tool for inclusion in mass spectrometry imaging workflows.
79
Dimensionality reduction of mass spectrometry imaging data using autoencoders
Spencer A. Thomas,Alan M. Race,Rory T. Steven,Ian S. Gilmore,Josephine Bunch +4 more
- 01 Dec 2016
TL;DR: The unsupervised method provides the MSI community with an effective non-linear dimensionality reduction technique which includes the mapping to and from the reduced dimensional space.
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Optimisation of colour schemes to accurately display mass spectrometry imaging data based on human colour perception
TL;DR: This article considers the suitability of colour schemes and composite image formation found in MSI literature in the context of human colour perception and discusses recommendations of rules for colour scheme selection for ion composites and multivariate analysis techniques such as principal component analysis (PCA).
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