Alan Lai
Heidelberg University
17 Papers
39 Citations
Alan Lai is an academic researcher from Heidelberg University. The author has contributed to research in topics: Lie group & Dirac (software). The author has an hindex of 7, co-authored 17 publications. Previous affiliations of Alan Lai include University of Toronto & California Institute of Technology.
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Papers
Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy.
Farbod Sedaghat-Hamedani,Jan Haas,Feng Zhu,Feng Zhu,Christian Geier,Elham Kayvanpour,Martin Liss,Alan Lai,Karen S. Frese,Regina Pribe-Wolferts,Ali Amr,Daniel Tian Li,Omid Shirvani Samani,Avisha Carstensen,Diana Martins Bordalo,Marion Müller,Christine Fischer,Jing Shao,Jing Wang,Ming Nie,Li Yuan,Sabine Haßfeld,Christine Schwartz,Min Zhou,Zihua Zhou,Yan-Wen Shu,Min Wang,Kai Huang,Qiutang Zeng,Long-Xian Cheng,Tobias Fehlmann,Philipp Ehlermann,Andreas Keller,Christoph Dieterich,Katrin Streckfuß-Bömeke,Yuhua Liao,Michael Gotthardt,Hugo A. Katus,Benjamin Meder +38 more
TL;DR: The data demonstrate that the clinical course of symptomatic LVNC can be severe and the identified pathogenic variants and distribution of disease genes-a titin-related pathomechanism is found in every fourth patient-should be considered in genetic counselling of patients.
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Genotype-phenotype associations in dilated cardiomyopathy: meta-analysis on more than 8000 individuals.
Elham Kayvanpour,Farbod Sedaghat-Hamedani,Ali Amr,Alan Lai,Jan Haas,Daniel B. Holzer,Karen S. Frese,Andreas Keller,Katrin Jensen,Hugo A. Katus,Benjamin Meder +10 more
TL;DR: A pooled analysis of available genotype-phenotype data shows a higher prevalence of sudden cardiac death (SCD), cardiac transplantation, or ventricular arrhythmias in LMNA and PLN mutation carriers compared to sarcomeric gene mutations.
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Epigenome-Wide Association Study Identifies Cardiac Gene Patterning and a Novel Class of Biomarkers for Heart Failure.
Benjamin Meder,Jan Haas,Farbod Sedaghat-Hamedani,Elham Kayvanpour,Karen S. Frese,Alan Lai,Rouven Nietsch,Christina Scheiner,Stefan Mester,Diana Martins Bordalo,Ali Amr,Carsten Dietrich,Dietmar Pils,Dominik Siede,Hauke Hund,Andrea S. Bauer,Daniel B. Holzer,Arjang Ruhparwar,Matthias Mueller-Hennessen,Dieter Weichenhan,Christoph Plass,Tanja Weis,Johannes Backs,Maximilian Wuerstle,Andreas Keller,Hugo A. Katus,Andreas E. Posch +26 more
TL;DR: This first epigenome-wide association study in living patients with heart failure using a multi-omics approach links a subset of 517 epigenetic loci with dilated cardiomyopathy and cardiac gene expression and identifies distinct epigenetic methylation patterns that are conserved across tissues.
176
Clinical outcomes associated with sarcomere mutations in hypertrophic cardiomyopathy: a meta-analysis on 7675 individuals
Farbod Sedaghat-Hamedani,Elham Kayvanpour,Oguz Firat Tugrul,Alan Lai,Ali Amr,Jan Haas,Tanja Proctor,Philipp Ehlermann,Katrin Jensen,Hugo A. Katus,Benjamin Meder +10 more
TL;DR: A pooled dataset and comprehensive genotype–phenotype analysis show that the age at disease onset of HCM patients with MYH7 is earlier and leads to a more severe phenotype than in patient without such mutations, and patients with sarcomeric mutations are more susceptible to SCD.
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