Alan J. Grodzinsky
Massachusetts Institute of Technology
397 Papers
4.1K Citations
Alan J. Grodzinsky is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Cartilage & Aggrecan. The author has an hindex of 90, co-authored 377 publications. Previous affiliations of Alan J. Grodzinsky include Brigham and Women's Hospital.
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Papers
Effects of matrix metalloproteinases on cartilage biophysical properties in vitro and in vivo.
Lawrence J. Bonassar,Claribel G. Paguio,Eliot H. Frank,Kimberly A. Jeffries,Vernon L. Moore,Michael W. Lark,Charles G. Caldwell,William K. Hagmann,Alan J. Grodzinsky +8 more
TL;DR: This study quantifies the changes in cartilage physical properties due to APMA-activated endogenous MMP, characterize the effect of selected MMP inhibitors on these physical changes, and quantify the effects of intraarticular injection of rhSLN on cartilage material properties and modulation by the systemic administration of an MMP inhibitor.
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Variable permeability membranes : network structure of poly(methacrylic acid) and its relation to diffusive transport
TL;DR: In this article, the crosslink density and solvent-polymer interaction parameter of uncharged PMAA membranes were derived from tensile force and polymer volume fraction data, using the method of Meissner and Janacek.
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•Journal Article
Quantitative electrical impedance analysis of cartilage degradation.
TL;DR: The electrical impedance of the articulating surface of intact joints is measured to gauge enzymatic degradation in vitro bovine articular cartilage, OA degradation in human patellae, and canine model graft repair tissue by comparing impedance measurements with biomechanical measurements, biochemical analyses, and histology.
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Introduction to Articular Cartilage
David Smith,Bruce S. Gardiner,Lihai Zhang,Alan J. Grodzinsky +3 more
- 01 Jan 2019
TL;DR: Measurements suggest 5 MPa to 6 MPa is experienced by large joints during gait and up to 18 MPa rising from a chair and numerical experiments suggest peak contact stresses while walking of between 4 MPa and 7 MPa (Venalainen et al. 2016).
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