Alan J. Grodzinsky
Massachusetts Institute of Technology
397 Papers
4.1K Citations
Alan J. Grodzinsky is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Cartilage & Aggrecan. The author has an hindex of 90, co-authored 377 publications. Previous affiliations of Alan J. Grodzinsky include Brigham and Women's Hospital.
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Papers
Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration.
Paula M. Ragan,Alison M. Badger,Michael Cook,Vicki I. Chin,Maxine Gowen,Alan J. Grodzinsky,Michael W. Lark +6 more
TL;DR: The results suggest that mechanical compression rapidly alters chondrocyte aggrecan and type‐II collagen gene expression on application of load, and indicate that the observed decreases in biosynthesis may not be related solely to changes in mRNA expression.
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Electrically modulated membrane permeability
TL;DR: Results suggest that the electric field acts as a switch to control the swelling state and the resulting pore size of the membrane.
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Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term
TL;DR: In this article, a single-dose Avidin-delivered DEX can ameliorate catabolic effects in cytokine-challenged cartilage relevant to post-traumatic OA.
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Chondrocyte extracellular matrix synthesis and turnover are influenced by static compression in a new alginate disk culture system.
Paula M. Ragan,Vicki I. Chin,Han-Hwa K. Hung,Koichi Masuda,Eugene J.-M.A. Thonar,Elizabeth C. Arner,Alan J. Grodzinsky,John D. Sandy +7 more
TL;DR: The results show that chondrocyte function is maintained in an alginate disk culture system and that this culture system is a useful model to examine chondROcyte ECM assembly and some aspects of catabolism normally found in vivo.
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Effects of Insulin-like Growth Factor-1 and Dexamethasone on Cytokine-Challenged Cartilage: Relevance to Post Traumatic Osteoarthritis
Yang Li,Yang Wang,S. Chubinskaya,Birgit Schoeberl,Emily Florine,Paul W. Kopesky,Alan J. Grodzinsky +6 more
TL;DR: In this paper, the combined use of insulin-like growth factor-1 (IGF-1) and dexamethasone (Dex) was studied to block the multiple degradative effects of cytokine challenge to articular cartilage.
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