Alan Gillett
Karolinska Institutet
17 Papers
204 Citations
Alan Gillett is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Gene. The author has an hindex of 14, co-authored 17 publications. Previous affiliations of Alan Gillett include Karolinska University Hospital.
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Papers
Adoptive Transfer of Immunomodulatory M2 Macrophages Prevents Type 1 Diabetes in NOD Mice
Roham Parsa,Pernilla Andresen,Alan Gillett,Sohel Mia,Xing-Mei Zhang,Sofia Mayans,Dan Holmberg,Robert A. Harris +7 more
TL;DR: It is suggested that M2r macrophage therapy represents a novel intervention that stops ongoing autoimmune T1D and may have relevance in a clinical setting.
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Expression of Ccl11 Associates with Immune Response Modulation and Protection against Neuroinflammation in Rats
Milena Z. Adzemovic,Milena Z. Adzemovic,Johan Öckinger,Manuel Zeitelhofer,Sonja Hochmeister,Sonja Hochmeister,Amennai Daniel Beyeen,Atul Paulson,Alan Gillett,Melanie Thessen Hedreul,Ruxandra Covacu,Hans Lassmann,Tomas Olsson,Maja Jagodic +13 more
TL;DR: A congenic rat strain with Eae18b locus containing a chemokine cluster from the EAE- resistant PVG rat strain on the susceptible DA background was established and utilized myelin oligodendrocyte glycoprotein (MOG)-induced EAE to characterize the mechanisms underlying the genetic regulation of neuroinflammation.
Next-generation sequencing identifies microRNAs that associate with pathogenic autoimmune neuroinflammation in rats.
Petra Bergman,Tojo James,Lara Kular,Sabrina Ruhrmann,Tatiana Kramarova,Anders Kvist,Gordana Supic,Alan Gillett,Andor Pivarcsi,Maja Jagodic +9 more
TL;DR: This study characterized miRNAs that associate with susceptibility to develop experimental autoimmune encephalomyelitis in rats, a well-established animal model of MS, and demonstrated that these three genes are direct targets of miR-181a.
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Acute treatment with valproic acid and l-thyroxine ameliorates clinical signs of experimental autoimmune encephalomyelitis and prevents brain pathology in DA rats.
Gonçalo Castelo-Branco,Pernilla Stridh,André Ortlieb Guerreiro-Cacais,Milena Z. Adzemovic,Ana Mendanha Falcão,Monica Marta,Rasmus Berglund,Alan Gillett,Kedir Hussen Hamza,Hans Lassmann,Ola Hermanson,Maja Jagodic +11 more
TL;DR: It is found that a brief treatment after disease onset led to sustained amelioration of EAE and prevention of inflammatory demyelination in the CNS accompanied with a higher expression of myelin-related genes in the brain.
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Multiple loci comprising immune-related genes regulate experimental neuroinflammation.
Monica Marta,Monica Marta,Pernilla Stridh,Kristina Becanovic,Alan Gillett,Johan Öckinger,Johnny C. Lorentzen,Maja Jagodic,Tomas Olsson +8 more
TL;DR: By demonstrating several QTLs comprising immune-related genes, which potentially interact, this work provides a significant step toward elucidation of the polygenically regulated pathogenesis of MOG-EAE and possibly multiple sclerosis (MS), and opportunities for comparative genetics and testing in MS case–control cohorts.
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