Alan Dodge
St Mary's Hospital
2 Papers
Alan Dodge is an academic researcher from St Mary's Hospital. The author has contributed to research in topics: Trinucleotide repeat expansion & Huntington's disease. The author has an hindex of 2, co-authored 2 publications.
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Papers
Structure and expression of the Huntington's disease gene: Evidence against simple inactivation due to an expanded CAG repeat
Christine Ambrose,Mabel P. Duyao,Glenn Barnes,Gillian P. Bates,Carol Lin,Jayalakshmi Srinidhi,Sarah Baxendale,Holger Hummerich,Hans Lehrach,Michael R. Altherr,John J. Wasmuth,Alan Buckler,Deanna Church,David E. Housman,Mary Berks,Gos Micklem,Richard Durbin,Alan Dodge,Andrew P Read,James F. Gusella,Marcy E. MacDonald +20 more
TL;DR: Observations suggest that the dominant HD mutation either confers a new property on the mRNA or alters an interaction at the protein level, suggesting the operation of interacting factors in determining specificity of cell loss.
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Clinical presentation and patterns of regional cerebral atrophy related to the length of trinucleotide repeat expansion in patients with adult onset Huntington's disease
TL;DR: Tissue atrophy in advanced HD is unrelated to the underlying genetic defect, and CAG repeat number correlated inversely with age at onset and death, but not with disease duration or initial symptoms.
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