Alain Hovnanian
University of Paris
283 Papers
1.5K Citations
Alain Hovnanian is an academic researcher from University of Paris. The author has contributed to research in topics: Netherton syndrome & Medicine. The author has an hindex of 67, co-authored 256 publications. Previous affiliations of Alain Hovnanian include Paris Diderot University & Necker-Enfants Malades Hospital.
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Papers
EGFR signaling is overactive in Pachyonychia congenita: effective treatment with oral erlotinib.
TL;DR: In this paper , the authors showed that EGFR activation was confirmed by upregulated MAPK/ERK and mTOR signaling in Pachyonychia congenita (PC) lesions.
Successful treatment of JAK1 associated inflammatory disease.
Antoine Fayand,Véronique Hentgen,Celine Posseme,Carole Lacout,Capucine Picard,Philippe Moguelet,Margaux Cescato,Nabiha Sbeih,Thomas Moreau,Yi Zhu,Jean-Luc Charuel,Aurélien Corneau,Joelle Deibener-Kaminsky,Stéphanie Dupuy,Mathieu Fusaro,Bénédicte Hoareau,Alain Hovnanian,V. Langlois,Laurent Le Corre,Thiago Trovati Maciel,S. Miskinyte,Makoto Miyara,Thomas Moulinet,Magali Perret,Marie-Hélène Schuhmacher,Rachel Rignault-Bricard,Sébastien Viel,Angélique Vinit,Angèle Soria,Darragh Duffy,Jean-Marie Launay,Jacques Callebert,Jean-Philippe Herbeuval,Mathieu P Rodero,Sophie Georgin-Lavialle +34 more
TL;DR: In this article , the authors identified a family affected by JAK1 associated autoinflammatory disease and performed clinical assessment and immunological monitoring on 9 patients, who were treated with one of two JAK inhibitors; either baricitinib or upadacitinib.
Darier disease : A disease model of impaired calcium homeostasis in the skin
Magali Savignac,Anissa Edir,Anissa Edir,Marina Simón,Marina Simón,Alain Hovnanian,Alain Hovnanian +6 more
TL;DR: The role of SERCA2 pumps and calcium in normal epidermis is reviewed, and the consequences of ATP2A2 mutations on Ca(2+) signaling in DD are discussed.
Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis
Matthieu Lacroix,Julie Caramel,Perrine Goguet-Rubio,Laetitia K. Linares,Soline Estrach,Elodie Hatchi,Geneviève Rodier,Gwendaline Lledo,Carine de Bettignies,Amélie Thépot,Céline Deraison,Karim Chebli,Alain Hovnanian,Pierre Hainaut,Pierre Dubus,Claude Sardet,Laurent Le Cam +16 more
TL;DR: A regulatory axis essential for ESC-dependent skin homeostasis implicating E4F1 and the Bmi1–Arf–p53 pathway is identified and identified, indicating that the lesions observed in the E 4F1 mutant skin result, at least in part, from cell-autonomous alterations in ESC maintenance.
DNA-Based Prenatal Diagnosis of Harlequin Ichthyosis and Characterization of ABCA12 Mutation
Consequences Akiyama,Matthias Titeux,Kaori Sakai,James R. McMillan,Laure Tonasso,Patrick Calvas,Frederique Jossic,Alain Hovnanian,Hiroshi Shimizu +8 more
- 01 Jan 2007
TL;DR: In this paper, the first case of prenatal diagnosis for harlequin ichthyosis (HI) DNA-based PD was reported, which revealed that the deceased proband was a compound heterozygote for two novel mutations.