Alain Fischer
University of Paris
805 Papers
7.3K Citations
Alain Fischer is an academic researcher from University of Paris. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 143, co-authored 770 publications. Previous affiliations of Alain Fischer include French Institute of Health and Medical Research & Boston Children's Hospital.
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Papers
An influenza virus matrix protein‐specific human T cell line with helper activity for in vitro anti‐hemagglutinin antibody production
TL;DR: Evidence for matrix protein‐specific T helper cells and factors able to provide help for antibody production against hemagglutinin, a distinct protein of the same virus is provided.
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Spontaneous IgM Autoantibody Production In Vitro by B Lymphocytes of Normal Human Neonates
TL;DR: In the absence of in vitro stimulation, human neonate B lymphocytes produce polyreactive antibodies of the IgM isotype against several autoantigens, similar to that ofpolyreactive autoantibody‐producing B cells in mice.
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Blockade of the integrin αLβ2 but not of integrins α4 and/or β7 significantly prolongs intestinal allograft survival in mice
Sabine Sarnacki,F Auber,Célia Crétolle,C. Camby,Marina Cavazzana-Calvo,Werner Müller,N Wagner,Nicole Brousse,Yann Revillon,Alain Fischer,Nadine Cerf-Bensussan +10 more
TL;DR: The results suggest that anti-LFA-1, but not anti-α4 mAb treatment, may be useful in improving the results of intestinal transplantation, and that this treatment is not incompatible with long term administration of tacrolimus currently used in the prevention of small bowel graft rejection in humans.
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CD34 stem cell top-ups without conditioning after initial haematopoietic stem cell transplantation for correction of incomplete haematopoietic and immunological recovery in severe congenital immunodeficiencies.
Claire Booth,Jean-Antoine Ribeil,Françoise Audat,Liliane Dal-Cortivo,Paul Veys,Adrian J. Thrasher,Adrian J. Thrasher,E. Graham Davies,François Lefrère,Alain Fischer,Marina Cavazzana-Calvo,H. Bobby Gaspar,H. Bobby Gaspar +12 more
TL;DR: A CD34+ cell infusion without conditioning has the potential to improve stem cell function with limited toxicity but should be given early after the original graft to be effective.
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Recent advances in understanding the pathophysiology of primary T cell immunodeficiencies.
TL;DR: A review of primary immunodeficiencies that affect adaptive immunity in general and T lymphocytes in particular and the analysis of PIDs is now opening up new pathways towards targeted therapies.
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