Alain Fischer
University of Paris
805 Papers
7.3K Citations
Alain Fischer is an academic researcher from University of Paris. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 143, co-authored 770 publications. Previous affiliations of Alain Fischer include French Institute of Health and Medical Research & Boston Children's Hospital.
Chat about Author
Papers
A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice.
Fernando E. Sepulveda,Fernando E. Sepulveda,Sophia Maschalidi,Sophia Maschalidi,Christian A. J. Vosshenrich,Alexandrine Garrigue,Alexandrine Garrigue,Mathieu Kurowska,Mathieu Kurowska,Gaël Ménasché,Gaël Ménasché,Alain Fischer,James P. Di Santo,Geneviève de Saint Basile,Geneviève de Saint Basile,Geneviève de Saint Basile +15 more
TL;DR: A crucial role is identified of NK-cell cytotoxicity in limiting HLH-like immunopathology, highlighting the important role of NK cytotoxic activity in immune homeostasis.
77
The pleiotropic movement disorders phenotype of adult ataxia-telangiectasia
Aurélie Méneret,Yara Ahmar-Beaugendre,Guillaume Rieunier,Nizar Mahlaoui,Bertrand Gaymard,Emmanuelle Apartis,Christine Tranchant,Sophie Rivaud-Péchoux,Bertrand Degos,Baya Benyahia,Felipe Suarez,Thierry Maisonobe,Michel Koenig,Alexandra Durr,Marc-Henri Stern,Catherine Dubois d'Enghien,Alain Fischer,Marie Vidailhet,Dominique Stoppa-Lyonnet,David Grabli,Mathieu Anheim +20 more
TL;DR: There is great variability of phenotype and severity in A-T, including a wide spectrum of movement disorders, and karyotype and repeated AFP level assessments should be performed in adults with unexplained movement disorders as valuable clues towards the diagnosis.
76
Human TCR α/β+ CD4−CD8− Double-Negative T Cells in Patients with Autoimmune Lymphoproliferative Syndrome Express Restricted Vβ TCR Diversity and Are Clonally Related to CD8+ T Cells
Anne Bristeau-Leprince,Anne Bristeau-Leprince,Véronique Mateo,Annick Lim,Annick Lim,Aude Magerus-Chatinet,Eric Solary,Alain Fischer,Frédéric Rieux-Laucat,Marie-Lise Gougeon,Marie-Lise Gougeon +10 more
TL;DR: Analysis of TCRVβ repertoire diversity of sorted DN and SP T cells shows that DN T cells express all the Vβ gene families that are used by their SP counterparts, though they dominantly use some Vβ genes.
75
Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.
Fernando E. Sepulveda,Fernando E. Sepulveda,Franck Debeurme,Franck Debeurme,Gaël Ménasché,Gaël Ménasché,Mathieu Kurowska,Mathieu Kurowska,Marjorie Côte,Marjorie Côte,Jana Pachlopnik Schmid,Jana Pachlopnik Schmid,Jana Pachlopnik Schmid,Alain Fischer,Alain Fischer,Alain Fischer,Geneviève de Saint Basile,Geneviève de Saint Basile,Geneviève de Saint Basile +18 more
TL;DR: The data indicate that cytotoxic effectors may have other immune-regulatory roles in addition to their role in controlling viral replication in patients with genetic abnormalities expected to result in the complete absence of perforin, Rab27a, or syntaxin-11.
75
Hematopoietic stem cell transplantation for Shwachman-Diamond syndrome: experience of the French neutropenia registry
J Donadieu,G. Michel,Etienne Merlin,Pierre Bordigoni,B Monteux,Blandine Beaupain,Guy Leverger,J. P. Laporte,Olivier Hermine,Agnes Buzyn,Yves Bertrand,Jean-Laurent Casanova,Thierry Leblanc,Eliane Gluckman,Alain Fischer,Jean-Louis Stephan +15 more
TL;DR: It is concluded that HSCT is feasible for patients with SDS who develop bone marrow failure or malignant transformation, and the overall 5-year event-free survival rate is 60±15%.