Alain Fischer
University of Paris
805 Papers
7.3K Citations
Alain Fischer is an academic researcher from University of Paris. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 143, co-authored 770 publications. Previous affiliations of Alain Fischer include French Institute of Health and Medical Research & Boston Children's Hospital.
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Papers
Gene therapy of severe combined immunodeficiencies
TL;DR: In this paper, a proof-of-concept for gene therapy has been provided using severe combined immunodeficiencies, where gene transfer can confer a selective advantage to transduced cells.
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Dysfunctions of Pokeweed Mitogen-stimulated T and B Lymphocyte Responses Induced by Gammaglobulin Therapy
TL;DR: The observations suggest that immunological effects of gammaglobulin therapy are not limited to antibody transfer, since it also induces subtle modifications of in vitro pokeweed mitogen-stimulated T and B cell responses.
Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.
Markus Bender,Markus Bender,Simon Stritt,Paquita Nurden,Judith M.M. van Eeuwijk,Barbara Zieger,Karim Kentouche,Harald Schulze,Henner Morbach,David Stegner,Katrin G. Heinze,Sebastian Dütting,Shuchi Gupta,Walter Witke,Hervé Falet,Alain Fischer,John H. Hartwig,Bernhard Nieswandt +17 more
TL;DR: It is reported that mice with a megakaryocyte/platelet-specific Pfn1 deficiency display microthrombocytopenia due to accelerated turnover of platelets and premature platelet release into the bone marrow.
Successful HLA nonidentical bone marrow transplantation in three patients with the leukocyte adhesion deficiency.
F Le Deist,Stéphane Blanche,H Keable,C Gaud,Hai Thanh Pham,B Descamp-Latscha,V Wahn,Claude Griscelli,Alain Fischer +8 more
TL;DR: It is proposed that the LFA-1 molecule plays a role in HLA-incompatible graft rejection, probably by mediating adhesion of cytotoxic T and non-T lymphocytes to their targets.
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The Common Cytokine Receptor γ Chain and the Pre-T Cell Receptor Provide Independent but Critically Overlapping Signals in Early α/β T Cell Development
James P. Di Santo,Iannis Aifantis,Eleftheria Rosmaraki,Corinne Garcia,Jacqueline Feinberg,Hans Jörg Fehling,Alain Fischer,Harald von Boehmer,Benedita Rocha +8 more
TL;DR: It is demonstrated that the pre-TCR provides the γc-independent signal which allows α/β T cell development in γ c − mice, and a series of overlapping signals derived from cytokine and T cell receptors guide the process of α/ β thymocyte development.
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