Alain Fischer
University of Paris
805 Papers
7.3K Citations
Alain Fischer is an academic researcher from University of Paris. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 143, co-authored 770 publications. Previous affiliations of Alain Fischer include French Institute of Health and Medical Research & Boston Children's Hospital.
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Papers
Severe combined immunodeficiencies (SCID)
TL;DR: Only those SCIDs with severe T cell depletion will be discussed here, leaving those who usually have normal T cell numbers for a separate review.
Allogeneic hematopoietic stem-cell transplantation for leukocyte adhesion deficiency.
Waseem Qasim,Marina Cavazzana-Calvo,EG Davies,Jeffrey H. Davis,Michel Duval,Gretchen Eames,N Farinha,A Filopovich,Alain Fischer,Wilhelm Friedrich,Andrew R. Gennery,Carsten Heilmann,Paul Landais,Mitchell E. Horwitz,Fulvio Porta,Petr Sedlacek,Reinhard Seger,M Slatten,Lochie Teague,Mary Eapen,Paul Veys +20 more
TL;DR: Hematopoietic stem- cell transplantation offers long-term benefit in leukocyte adhesion deficiency and should be considered as an early therapeutic option if a suitable HLA-matched stem-cell donation is available.
Sensitivity of Epstein-Barr virus-induced B cell tumor to apoptosis mediated by anti-CD95/Apo-1/fas antibody.
TL;DR: Induction of apoptosis by an anti‐C95/Apo‐1/fas‐specific antibody could be applied for therapy ofEBV‐induced B cell tumors and contribute to the understanding of the mechanisms of T cell‐mediated elimination of EBV lymphomas in immunodeficient patients.
Activation-induced cytidine deaminase: structure-function relationship as based on the study of mutants.
TL;DR: Together, these data strongly suggest that AID, a master molecule for antibody diversification, exerts its activity on CSR not only as a cytidine deaminase enzyme but also as a docking protein, recruiting specific cofactors to a multimeric complex.