Akira Yamauchi
Kawasaki Medical School
167 Papers
940 Citations
Akira Yamauchi is an academic researcher from Kawasaki Medical School. The author has contributed to research in topics: Galectin & Breast cancer. The author has an hindex of 44, co-authored 150 publications. Previous affiliations of Akira Yamauchi include Nagasaki University & Center for Biologics Evaluation and Research.
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Papers
The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
Jian-Xin Lin,Thi-Sau Migone,Monica Tseng,Michael Friedmann,James A. Weatherbee,Li Zhou,Akira Yamauchi,Eda T. Bloom,Judy A. Mietz,Susan D. John,Warren J. Leonard +10 more
TL;DR: These studies demonstrate that a single cytokine can activate different combinations of Stat proteins under different physiological conditions, and also indicate two mechanisms by which distinct cytokines can activate the same Stat protein.
815
Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis
Masako Seki,Souichi Oomizu,Ken Mei Sakata,Atsuko Sakata,Tomohiro Arikawa,Kota Watanabe,Kanako Ito,Keisuke Takeshita,Toshiro Niki,Naoki Saita,Nozomu Nishi,Akira Yamauchi,Shigeki Katoh,Akihiro Matsukawa,Vijay K. Kuchroo,Mitsuomi Hirashima +15 more
TL;DR: It is suggested that galectin-9 ameliorates CIA by suppressing the generation of Th17, promoting the induction of regulatory T cells, and it suppresses differentiation to Th17 cells in vitro.
469
Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation
Masaya Ueno,Hiroshi Masutani,Roberto J. Arai,Akira Yamauchi,Kiichi Hirota,Toshiyuki Sakai,Takashi Inamoto,Yoshio Yamaoka,Junji Yodoi,Toshio Nikaido +9 more
TL;DR: TRX-dependent redox regulation of p53 activity indicates coupling of the oxidative stress response and p53-dependent repair mechanism.
444
Galectin-9 Increases Tim-3+ Dendritic Cells and CD8+ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions
Keiko Nagahara,Tomohiro Arikawa,Souichi Oomizu,Keiichi Kontani,Atsuya Nobumoto,Hiroaki Tateno,Kota Watanabe,Toshiro Niki,Shigeki Katoh,Minoru Miyake,Syun-Ichiro Nagahata,Jun Hirabayashi,Vijay K. Kuchroo,Akira Yamauchi,Mitsuomi Hirashima +14 more
TL;DR: It is demonstrated that Gal-9 prolongs the survival of Meth-A tumor-bearing mice in a dose- and time-dependent manner and potentiates CD8+ T cell-mediated antitumor immunity viaGal-9-Tim-3 interactions between DCs and CD8- T cells.
Fractalkine-Mediated Endothelial Cell Injury by NK Cells
Osamu Yoneda,Toshio Imai,Seiji Goda,Hiroshi Inoue,Akira Yamauchi,Toshio Okazaki,Hisao Imai,Osamu Yoshie,Eda T. Bloom,Naochika Domae,Hisanori Umehara +10 more
TL;DR: The results suggest that fractalkine plays an important role not only in the binding of NK cells to endothelial cells, but also in NK cell-mediated endothelium damage, which may result in vascular injury.
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