Akira Watanabe
Gunma University
128 Papers
387 Citations
Akira Watanabe is an academic researcher from Gunma University. The author has contributed to research in topics: Medicine & Hepatectomy. The author has an hindex of 15, co-authored 106 publications.
Chat about Author
Papers
Functional remnant liver volumetry using Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) predicts post-hepatectomy liver failure in resection of more than one segment
Kenichiro Araki,Norifumi Harimoto,Norio Kubo,Akira Watanabe,Takamichi Igarashi,Mariko Tsukagoshi,Norihiro Ishii,Yoshito Tsushima,Ken Shirabe +8 more
TL;DR: FRLV using LMR could precisely predict post-hepatectomy liver failure (PHLF) in resection of more than one segment, and was useful even in patients who underwent PVE.
54
Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts
Takahiro Yamanaka,Norifumi Harimoto,Takehiko Yokobori,Ryo Muranushi,Kouki Hoshino,Kei Hagiwara,Dolgormaa Gantumur,Tadashi Handa,Norihiro Ishii,Mariko Tsukagoshi,Takamichi Igarashi,Hiroshi Tanaka,Akira Watanabe,Norio Kubo,Kenichiro Araki,Ken Shirabe +15 more
TL;DR: The findings suggest that therapeutic strategies combining conventional cytotoxic agents with nintedanib targeting CAFs are promising for overcoming refractory ICC with activated CAFs.
53
High STMN1 expression is associated with cancer progression and chemo-resistance in lung squamous cell carcinoma
Pinjie Bao,Takehiko Yokobori,Bolag Altan,Misaki Iijima,Youko Azuma,Ryoichi Onozato,Toshiki Yajima,Akira Watanabe,Akira Mogi,Kimihiro Shimizu,Toshiteru Nagashima,Yoichi Ohtaki,Kai Obayashi,Seshiru Nakazawa,Tuya Bai,Reika Kawabata-Iwakawa,Takayuki Asao,Kyoichi Kaira,Masahiko Nishiyama,Hiroyuki Kuwano +19 more
TL;DR: The results suggest that STMN1 is a prognostic factor that also is associated with caner progression and chemo-resistance, and could be a predictor for poor prognosis and a potential therapeutic target in LSCC.
45
Relationship between LAT1 expression and resistance to chemotherapy in pancreatic ductal adenocarcinoma.
Bolag Altan,Kyoichi Kaira,Akira Watanabe,Norio Kubo,Pinjie Bao,Gantumur Dolgormaa,Erkhem-Ochir Bilguun,Kenichiro Araki,Yoshikatsu Kanai,Takehiko Yokobori,Tetsunari Oyama,Masahiko Nishiyama,Hiroyuki Kuwano,Ken Shirabe +13 more
TL;DR: LAT1 as an independent prognostic marker is a potential molecular targeting gene to reduce chemoresistance and tumor growth in patients with PDAC, supported by in vitro analysis of chemotherapy resistance and LAT1 function.
Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts.
Norihiro Ishii,Kenichiro Araki,Takehiko Yokobori,Kei Hagiwara,Dorgormaa Gantumur,Takahiro Yamanaka,Tadashi Handa,Mariko Tsukagoshi,Takamichi Igarashi,Akira Watanabe,Norio Kubo,Norifumi Harimoto,Atsushi Masamune,Kazuo Umezawa,Hiroyuki Kuwano,Ken Shirabe +15 more
TL;DR: It is shown that cancer‐associated fibroblasts (CAF) stimulated indicators of pancreatic cancer malignancy, such as proliferation, invasiveness, and chemoresistance, and that CnP suppressed CAF activity and proliferation, and inhibited the stimulating effects of CAF on pancreatic cancers cells.
34