Background/Aims: Magnesium is an essential mineral for many metabolic functions. There is very little information on the effect of magnesium supplementation on me

/pdf/magnesium-replacement-improves-the-metabolic-profile-in-3li2qnmub4.pdf

Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study

With the advent of next generation sequencing methods and progress in transcriptome analysis, it became obvious that the human genome contains much more than just protein-coding genes. In fact, up to 70% of our genome is transcribed into RNA that does not serve as templates for proteins. In this review, we focus on the emerging roles of these long non-coding RNAs (lncRNAs) in the field of tumor biology. Long ncRNAs were found to be deregulated in several human cancers and show tissue-specific expression. Functional studies revealed a broad spectrum of mechanisms applied by lncRNAs such as HOTAIR, MALAT1, ANRIL or lincRNA-p21 to fulfill their functions. Here, we link the cellular processes influenced by long ncRNAs to the hallmarks of cancer and therefore provide an ncRNA point-of-view on tumor biology. This should stimulate new research directions and therapeutic options considering long ncRNAs as novel prognostic markers and therapeutic targets.

https://www.tandfonline.com/doi/pdf/10.4161/rna.20481

The hallmarks of cancer: a long non-coding RNA point of view.

CA : A Cancer Journal for Clinicians

One signal that is overactivated in a wide range of tumour types is the production of a phospholipid, phosphatidylinositol (3,4,5) trisphosphate, by phosphatidylinositol 3-kinase (PI3K) This lipid and the protein kinase that is activated by it — AKT — trigger a cascade of responses, from cell growth and proliferation to survival and motility, that drive tumour progression Small-molecule therapeutics that block PI3K signalling might deal a severe blow to cancer cells by blocking many aspects of the tumour-cell phenotype

The phosphatidylinositol 3-Kinase AKT pathway in human cancer.

The repair of wounds is one of the most complex biological processes that occur during human life. After an injury, multiple biological pathways immediately become activated and are synchronized to respond. In human adults, the wound repair process commonly leads to a non-functioning mass of fibrotic tissue known as a scar. By contrast, early in gestation, injured fetal tissues can be completely recreated, without fibrosis, in a process resembling regeneration. Some organisms, however, retain the ability to regenerate tissue throughout adult life. Knowledge gained from studying such organisms might help to unlock latent regenerative pathways in humans, which would change medical practice as much as the introduction of antibiotics did in the twentieth century.

/pdf/wound-repair-and-regeneration-1rzgi7hifn.pdf

Wound repair and regeneration

Selective Growth and Schottky Diode Characteristics of β-SiC Single Crystal Films on Si (111) Substrates by Chemical Vapor Deposition

/pdf/erratum-hyperactive-mtor-signals-in-the-proopiomelanocortin-shd611wdol.pdf

Erratum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice (Scientific Reports (2016) 6 (22991) DOI: 10.1038/srep22991)

PROBLEM TO BE SOLVED: To improve yield when mounted, achieve cost reduction and improve external luminance efficiency. SOLUTION: This P-N junction type light-emitting diode has a P-N junction structure, constituted of an N-type and a P-type semiconductor layers which are formed on a substrate having light transparency. The light-emitting diode is provided with an ohmic electrode which is arranged on an upper surface of the P-N junction structure and constituted of a metal film, having optical transparency and an ohmic electrode which is arranged on a substrate surface opposite to the substrate surface on which the P-N junction structure is laminated and whose area is smaller than that of the substrate surface.

P-n junction type light-emitting diode

A cartridge detachably mountable to a main assembly of an image forming apparatus includes a cartridge frame formed of a resin material; a plurality of resin members molded on the cartridge frame by injection molding of a resin material different from that of the cartridge frame; a plurality of contact surfaces, provided on the cartridge frame, to which metal molds corresponding to the resin members are to be contacted from the same side when the resin members are molded; and a plurality of resin material inlet ports, provided in an opposite side of said cartridge frame from a side where the contact surfaces are provided. The resin material has been flowed into the cartridge frame when the resin members are molded.

Cartridge and unit for an electrophotographic image forming apparatus

PROBLEM TO BE SOLVED: To restrain the deformation of both side walls of a cleaning frame body by providing a reinforcing member between the side wall on either side and the side wall on the other end side in the longitudinal direction of the cleaning frame body on an opposite side to a side where an exposure aperture is formed. SOLUTION: The frame body of a cleaning means is composed of the main body 13q of the cleaning frame body and a cover. Then, a cleaning unit is constituted by integrally assembling a photoreceptor drum, a cleaning blade, a scoop sheet and an electrifying roller functioning as an electrifying means in one main body 13q. In such constitution, a rib extended all over the area in a longitudinal direction is provided as the reinforcing member of the cleaning frame body inside the main body 13q. It is conceivable to fix a sheet metal 159 on both ends 13s inside the main body 13q through small screws 159a and the like by using the sheet metal 159 instead of the rib. Thus, the cleaning frame body which is hardly thermally deformed and the process cartridge equipped with the cleaning frame body are obtained.

Cleaning frame body, process cartridge and electrophotographic image forming device

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