Background/Aims: Magnesium is an essential mineral for many metabolic functions. There is very little information on the effect of magnesium supplementation on me

/pdf/magnesium-replacement-improves-the-metabolic-profile-in-3li2qnmub4.pdf

Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study

With the advent of next generation sequencing methods and progress in transcriptome analysis, it became obvious that the human genome contains much more than just protein-coding genes. In fact, up to 70% of our genome is transcribed into RNA that does not serve as templates for proteins. In this review, we focus on the emerging roles of these long non-coding RNAs (lncRNAs) in the field of tumor biology. Long ncRNAs were found to be deregulated in several human cancers and show tissue-specific expression. Functional studies revealed a broad spectrum of mechanisms applied by lncRNAs such as HOTAIR, MALAT1, ANRIL or lincRNA-p21 to fulfill their functions. Here, we link the cellular processes influenced by long ncRNAs to the hallmarks of cancer and therefore provide an ncRNA point-of-view on tumor biology. This should stimulate new research directions and therapeutic options considering long ncRNAs as novel prognostic markers and therapeutic targets.

https://www.tandfonline.com/doi/pdf/10.4161/rna.20481

The hallmarks of cancer: a long non-coding RNA point of view.

CA : A Cancer Journal for Clinicians

One signal that is overactivated in a wide range of tumour types is the production of a phospholipid, phosphatidylinositol (3,4,5) trisphosphate, by phosphatidylinositol 3-kinase (PI3K) This lipid and the protein kinase that is activated by it — AKT — trigger a cascade of responses, from cell growth and proliferation to survival and motility, that drive tumour progression Small-molecule therapeutics that block PI3K signalling might deal a severe blow to cancer cells by blocking many aspects of the tumour-cell phenotype

The phosphatidylinositol 3-Kinase AKT pathway in human cancer.

The repair of wounds is one of the most complex biological processes that occur during human life. After an injury, multiple biological pathways immediately become activated and are synchronized to respond. In human adults, the wound repair process commonly leads to a non-functioning mass of fibrotic tissue known as a scar. By contrast, early in gestation, injured fetal tissues can be completely recreated, without fibrosis, in a process resembling regeneration. Some organisms, however, retain the ability to regenerate tissue throughout adult life. Knowledge gained from studying such organisms might help to unlock latent regenerative pathways in humans, which would change medical practice as much as the introduction of antibiotics did in the twentieth century.

/pdf/wound-repair-and-regeneration-1rzgi7hifn.pdf

Wound repair and regeneration

PROBLEM TO BE SOLVED: To provide a container for electrophotographic toner giving images with stable developing property and no degradation of picture quality due to development stripes even when a great number of sheets are continuously printed in a high temperature and high humidity environment. SOLUTION: The container for an electrophotographic toner stores the toner, wherein a thermoplastic elastomer is used as a toner sealing member. In the molecular weight distribution chart of the molecular weight of the thermoplastic elastomer in terms of a tetrahydrofuran soluble content fraction measured by gel permeation chromatography, an area ratio of a component having a molecular weight of 800 or less to the whole ranges from 0.05% to 30.00%. The toner contains toner particles and an inorganic fine powder. When methanol concentrations (%) during 50% transmittance by methanol wettability tests after the toner particles are left to stand in environments of 20°C and 40°C for 5 hours, are defined as D20 and D40, respectively, relationships of 10.0≤D20≤40.0 and 0≤D40-D20≤2.0 are satisfied. COPYRIGHT: (C)2010,JPO&INPIT

Container for electrophotographic toner and image forming method

A Case of Intramucosal Adenocarcinoma (pT1a-DMM) of Barrett’s Esophagus with Lymph Node Metastasis

/pdf/a-case-of-repeated-intestinal-obstruction-due-to-an-ileal-5ektx9qlir.pdf

A Case of Repeated Intestinal Obstruction due to an Ileal Duplication Cyst Containing Enterolith

A case of synchronous esophageal and gastric cancer treated by a mediastinoscopy-assisted esophagectomy and total gastrectomy

Resin moulded article, its mfg. method and resin injection appts. therein

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