Akio Kanatani
Merck & Co.
127 Papers
1.6K Citations
Akio Kanatani is an academic researcher from Merck & Co.. The author has contributed to research in topics: Neuropeptide Y receptor & Receptor. The author has an hindex of 36, co-authored 125 publications.
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Papers
Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice.
Takaharu Maruyama,Kenichi Tanaka,Jun Suzuki,Hiroyuki Miyoshi,Naomoto Harada,Takao Nakamura,Yasuhisa Miyamoto,Akio Kanatani,Yoshitaka Tamai +8 more
TL;DR: Female Gpbar1 homozygous mice showed significant fat accumulation with body weight gain compared with that of the wild-type mice, indicating that Gp bar1 is a potential new player in energy homeostasis.
Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R
Andreas W. Sailer,Hideki Sano,Zhizhen Zeng,Terrence P. McDonald,Jie Pan,Sheng Shung Pong,Scott D. Feighner,Carina P. Tan,Takehiro Fukami,Hisashi Iwaasa,Donna L. Hreniuk,Nancy R. Morin,Sharon J. Sadowski,Makoto Ito,Masahiko Ito,Alka Bansal,Betty Ky,David J. Figueroa,Qingping Jiang,Christopher P. Austin,Douglas J. MacNeil,Akane Ishihara,Masaki Ihara,Akio Kanatani,Lex H.T. Van der Ploeg,Andrew D. Howard,Qingyun Liu +26 more
TL;DR: The characterization of a second mammalian G protein-coupled receptor for MCH potentially indicates that the control of energy homeostasis in mammals by the MCH neuropeptide system may be more complex than initially anticipated.
256
Longitudinal analysis of murine steatohepatitis model induced by chronic exposure to high-fat diet.
Makoto Ito,Jun Suzuki,Shigeharu Tsujioka,Minoru Sasaki,Akira Gomori,Takashi Shirakura,Hiroyasu Hirose,Masahiko Ito,Akane Ishihara,Hisashi Iwaasa,Akio Kanatani +10 more
TL;DR: This paper found that long-term high-fat diet (HFD) exposure induces NASH, with excess body weight, hyperinsulinemia and hypercholesteremia in mice.
252
Chronic intracerebroventricular infusion of MCH causes obesity in mice
Akira Gomori,Akane Ishihara,Masahiko Ito,Satoshi Mashiko,Hiroko Matsushita,Mariko Yumoto,Makoto Ito,Takeshi Tanaka,Shigeru Tokita,Minoru Moriya,Hisashi Iwaasa,Akio Kanatani +11 more
TL;DR: It is suggested that chronic stimulation of the brain MCH system causes obesity in mice and imply that MCH may have a major role in energy homeostasis.
232
Characterization of MCH-mediated obesity in mice.
Masahiko Ito,Akira Gomori,Akane Ishihara,Zenjun Oda,Satoshi Mashiko,Hiroko Matsushita,Mariko Yumoto,Makoto Ito,Hideki Sano,Shigeru Tokita,Minoru Moriya,Hisashi Iwaasa,Akio Kanatani +12 more
TL;DR: The activation of MCH neuronal pathways stimulated adiposity, in part resulting from increased lipogenesis in liver and WAT and reduced energy expenditure in BAT, which confirms that modulation of energy homeostasis by MCH may play a critical role in the development of obesity.
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