Akiko Morikawa
Kyushu University
20 Papers
279 Citations
Akiko Morikawa is an academic researcher from Kyushu University. The author has contributed to research in topics: Amino acid & Biology. The author has an hindex of 18, co-authored 20 publications.
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Papers
D-Amino acids in mammals and their diagnostic value.
TL;DR: In this article, analytical methods including chromatographic, electrophoretic and enzymatic methods to determine D-amino acids in mammalian tissues are reviewed, and the distribution of these DAMINO acids in mammals is discussed.
205
Determination of free D-aspartic acid, D-serine and D-alanine in the brain of mutant mice lacking D-amino acid oxidase activity.
TL;DR: A simple and precise method for the simultaneous determination of free D-aspartic acid, D-serine and D-alanine in mouse brain tissues was established, using a reversed-phase HPLC system with widely used pre-column derivatizing reagents, o-phthaldialdehyde and N-t-butyloxycarbonyl-L-cysteine.
144
Comprehensive analysis of branched aliphatic D-amino acids in mammals using an integrated multi-loop two-dimensional column-switching high-performance liquid chromatographic system combining reversed-phase and enantioselective columns.
TL;DR: The described two-dimensional analysis concept proved to be successful for the given task in biological samples taken from mammals and indicates the ubiquitous presence of this unusual D-amino acid and the potential need to clarify its unique metabolism in mammals.
112
A Genetic Variant of the Serine Racemase Gene Is Associated with Schizophrenia
Yukitaka Morita,Hiroshi Ujike,Yuji Tanaka,Kyohei Otani,Makiko Kishimoto,Akiko Morio,Tatsuya Kotaka,Yuko Okahisa,Masayuki Matsushita,Akiko Morikawa,Kenji Hamase,Kiyoshi Zaitsu,Shigetoshi Kuroda +12 more
TL;DR: The IVS1a+465C allele of the SRR gene, which reduces expression of the gene, is a risk factor for schizophrenia, especially the paranoid subtype.
112
Determination of D-alanine in the rat central nervous system and periphery using column-switching high-performance liquid chromatography.
TL;DR: The anatomical distribution of free D-ala in the rat central nervous system and periphery has been investigated and the amount of D-Ala is significantly higher during the daytime than during the nighttime.
108